https://scholars.lib.ntu.edu.tw/handle/123456789/572929
標題: | Does bariatric surgery influence plasma levels of fetuin-A and leukocyte cellderived chemotaxin-2 in patients with type 2 diabetes mellitus? | 作者: | Huang H.-H Yeh C JEN-CHIH CHEN Lee T.-H Chen S.-C Lee W.-J Chen C.-Y. |
關鍵字: | C peptide; chemotaxin; fetuin A; hemoglobin A1c; leukocyte cell derived chemotaxin 2; triacylglycerol; unclassified drug; adult; anthropometry; Article; bariatric surgery; blood level; body mass; clinical article; female; gastric bypass surgery; glucose blood level; homeostasis model assessment; human; insulin resistance; leukocyte; male; non insulin dependent diabetes mellitus; obesity; sleeve gastrectomy; waist hip ratio | 公開日期: | 2018 | 卷: | 2018 | 期: | 6 | 來源出版物: | PeerJ | 摘要: | Background. Fetuin-A and leukocyte cell-derived chemotaxin-2 (LECT-2) are liverderived proteins. Fetuin-A is an independent risk factor for type 2 diabetes (T2D) and obese patients with T2D have higher plasma fetuin-A levels than those without T2D. LECT-2 has positive correlation with the severity of both obesity and insulin resistance. The changes in plasma fetuin-A are not consistent after bariatric surgery and no studies have investigated the changes in LECT-2 on the obese patients with T2D after bariatric surgery. Methods. Overall, 18 patients undergoing gastric bypass (GB) and 16 patients undergoing sleeve gastrectomy (SG) were enrolled. The fasting plasma fetuin-A and LECT-2 levels were measured at baseline, one week, three months, and one year after surgery. Results. Both the GB and SG groups significantly decreased the body mass index (BMI), waist-to-hip ratio, a body shape index; the triglyceride, fasting blood sugar (FBS), hemoglobin A1c, C-peptide levels; and homeostatic model assessment (HOMA-IR) one year after surgery. The SG group showed a decreasing trend in plasma fetuin-A levels one year after SG surgery. There are no significant changes in LECT-2 one year after either GB or SG. Fetuin-A had a near significant negative relationship with insulin (P = 0.056) and HOMA-IR (P = 0.050) in the SG group. Changes in fetuin-A had a significant positive relationship with changes in BMI (P = 0.031) and waist-to-hip ratio (P = 0.031) in the GB group and had a near significant positive correlation with FBS (P = 0.051) in the SG group. Discussion. Neither GB nor SG modifies plasma levels of plasma fetuin-A or LECT-2 in T2D patients after surgery. The changes in plasma fetuin-A have a positive correlation with those of the BMI and waist-to-hip ratio 12 months after GB. ? 2018 Huang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048586030&doi=10.7717%2fpeerj.4884&partnerID=40&md5=b2adb2d73b662f956d544eb707c8482e https://scholars.lib.ntu.edu.tw/handle/123456789/572929 |
ISSN: | 21678359 | DOI: | 10.7717/peerj.4884 |
顯示於: | 生物科技研究所 |
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