Dentinogenic ghost cell tumor in a Sumatran rhinoceros
Journal
Animals
Journal Volume
11
Journal Issue
4
Date Issued
2021
Author(s)
Abstract
An adult female Sumatran rhinoceros was observed with a swelling in the left infraorbital region in March 2017. The swelling rapidly grew into a mass. A radiograph revealed a cystic radiolucent area in the left maxilla. In June 2017, the rhinoceros was euthanized. At necropsy, the infraorbital mass measured 21 cm × 30 cm. Samples of the infraorbital mass, left parotid gland, and left masseter muscle were collected for histopathology (Hematoxylin & Eosin, Von Kossa, Masson’s trichrome, cytokeratin AE1/AE3, EMA, p53, and S-100). Numerous neoplastic epithelial cells showing pleomorphism and infiltration were observed. Islands of dentinoid material containing ghost cells and keratin pearls were observed with the aid of the two special histochemistry stains. Mitotic figures were rarely observed. All the neoplastic odontogenic cells and keratin pearls showed an intense positive stain for cytokeratin AE1/AE3, while some keratin pearls showed mild positive stains for S-100. All samples were negative for p53 and S-100 immunodetection. The mass was diagnosed as a dentinogenic ghost cell tumor. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
amoxicillin plus clavulanic acid; ceftiofur; cephalosporin; detomidine; dexamethasone; dexamethasone sodium phosphate; duphalyte; enrofloxacin; flunixin meglumine; glucose; infusion fluid; iron; ketamine; meglumine; pentobarbital; phenylbutazone; Ringer lactate solution; unclassified drug; vitamin K group; alveolar bone; Article; calcification; dentinogenic ghost cell tumor; Dicerorrhinus sumatrensis; dyspnea; epiphora; epistaxis; epithelium tumor; extant species; female; fracture; granulation tissue; histochemistry; histopathologic skin reaction; histopathology; immunohistochemistry; jaw cyst; keratin pearl; loss of appetite; mastication; maxilla fracture; mucopurulent exudate; nonhuman; odontogenic tumor; Staphylococcus; swabbing; swelling; tooth extraction; wound care; wound fluid; wound healing
Type
journal article