https://scholars.lib.ntu.edu.tw/handle/123456789/573233
標題: | Full-genome characterization of a novel Felis catus papillomavirus 4 subtype identified in a cutaneous squamous cell carcinoma of a domestic cat | 作者: | Yamashita-Kawanishi N Gushino Y Chang C.-Y HUI-WEN CHANG Chambers J.K Uchida K Haga T. |
關鍵字: | Felis catus papillomavirus type 4; PCR; Sequencing; Squamous cell carcinoma; Subtype | 公開日期: | 2021 | 來源出版物: | Virus Genes | 摘要: | The present study describes two full-genome sequences of Felis catus papillomavirus type 4 (FcaPV4) identified in squamous cell carcinoma (SCC) of two domestic cats. Two full-genome sequences of FcaPV4 were detected and characterized by PCR and sequencing. The L1 nucleotide sequence homology of one case showed 95.70% sequence identity to the reference FcaPV4, suggesting that this isolate should be classified as a subtype. Reverse-transcriptase PCR (RT-PCR) of two oncogenes, E6 and E7 was performed to confirm mRNA expression. Expression of E6 and E7 mRNA was detected in both cases, suggesting that FcaPV4 contributes to the development of SCC. This is the first report of FcaPV4 subtype. The present study will update the genomic features of FcaPV4 and contribute to deepening our knowledge about the etiological roles of FcaPV4 in feline cutaneous SCC. ? 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106530181&doi=10.1007%2fs11262-021-01843-y&partnerID=40&md5=86191710042ef0341ba5ce8511b3d9f5 https://scholars.lib.ntu.edu.tw/handle/123456789/573233 |
ISSN: | 9208569 | DOI: | 10.1007/s11262-021-01843-y | SDG/關鍵字: | complementary DNA; cyclin dependent kinase inhibitor 2A; messenger RNA; protein E6; protein E7; amino acid substitution; Article; clinical feature; domestic cat; Felis catus papillomavirus type 4; female; gene expression; gene sequence; genomics; male; mR |
顯示於: | 分子暨比較病理生物學研究所 |
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