https://scholars.lib.ntu.edu.tw/handle/123456789/573246
Title: | Investigation of silver (Ag) deposition in tissues from stranded cetaceans by autometallography (AMG) | Authors: | Li W.-T Chang H.-W Chen M.-H Chiou H.-Y Liou B.-Y Pang V.F Yang W.-C VICTOR FEI PANG Yang, Wei-cheng Jeng CR |
Keywords: | Deposition; Health; Histology; Inductively coupled plasma mass spectrometry; Liver; Marine pollution; Metabolism; Oceanography; Silver nanoparticles; Tissue; Autometallography; Cetacean; Commercial products; Inductively coupled plasma mass spectrometries (ICPMS); Infectious disease; Metabolic pathways; Metabolic profiles; Silver nanoparticles (AgNps); Silver compounds; silver; metal nanoparticle; silver; bioaccumulation; cell organelle; cetacean; concentration (composition); estimation method; inductively coupled plasma method; mass spectrometry; silver; adult; animal tissue; Article; autometallography; Cetacea; chemical analysis; concentration (parameters); controlled study; environmental impact; epithelium cell; female; Grampus griseus; kidney; kidney injury; Kogia; Kupffer cell; Lagenodelphis hosei; liver; liver cell; liver injury; male; mass spectrometry; metabolism; nonhuman; quantitative analysis; silver deposition; Stenella attenuata; water contamination; animal; Cetacea; environmental monitoring; Pacific Ocean; water pollutant; Cetacea; Rattus norvegicus; Animals; Cetacea; Environmental Monitoring; Liver; Male; Metal Nanoparticles; Pacific Ocean; Silver; Water Pollutants, Chemical | Issue Date: | 2018 | Journal Volume: | 235 | Start page/Pages: | 534-545 | Source: | Environmental Pollution | Abstract: | Silver, such as silver nanoparticles (AgNPs), has been widely used in commercial products and may be released into the environment. The interaction between Ag deposition and biological systems is raising serious concerns because of one health consideration. Cetaceans, as the top predators of the oceans, may be exposed to Ag/Ag compounds and suffer negative health impacts from the deposition of these compounds in their bodies. In the present study, we utilized autometallography (AMG) to localize the Ag in the liver and kidney tissues of cetaceans and developed a model called the cetacean histological Ag assay (CHAA) to estimate the Ag concentrations in the liver and kidney tissues of cetaceans. Our results revealed that Ag was mainly located in hepatocytes, Kupffer cells and the epithelial cells of some proximal renal tubules. The tissue pattern of Ag/Ag compounds deposition in cetaceans was different from those in previous studies conducted on laboratory rats. This difference may suggest that cetaceans have a different metabolic profile of Ag, so a presumptive metabolic pathway of Ag in cetaceans is advanced. Furthermore, our results suggest that the Ag contamination in cetaceans living in the North-western Pacific Ocean is more severe than that in cetaceans living in other marine regions of the world. The level of Ag deposition in cetaceans living in the former area may have caused negative impacts on their health condition. Further investigations are warranted to study the systemic Ag distribution, the cause of death/stranding, and the infectious diseases in stranded cetaceans with different Ag concentrations for comprehensively evaluating the negative health effects caused by Ag in cetaceans. Our results suggest that Ag contamination is more severe in cetaceans living in the North-western Pacific Ocean than in cetaceans living in other marine regions of the world and may have caused detrimental effects on their health condition. ? 2018 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044345498&doi=10.1016%2fj.envpol.2018.01.010&partnerID=40&md5=0427c379ab17ed71e760a163f845dd48 https://scholars.lib.ntu.edu.tw/handle/123456789/573246 |
ISSN: | 2697491 | DOI: | 10.1016/j.envpol.2018.01.010 | SDG/Keyword: | Deposition; Health; Histology; Inductively coupled plasma mass spectrometry; Liver; Marine pollution; Metabolism; Oceanography; Silver nanoparticles; Tissue; Autometallography; Cetacean; Commercial products; Inductively coupled plasma mass spectrometries (ICPMS); Infectious disease; Metabolic pathways; Metabolic profiles; Silver nanoparticles (AgNps); Silver compounds; silver; metal nanoparticle; silver; bioaccumulation; cell organelle; cetacean; concentration (composition); estimation method; inductively coupled plasma method; mass spectrometry; silver; adult; animal tissue; Article; autometallography; Cetacea; chemical analysis; concentration (parameters); controlled study; environmental impact; epithelium cell; female; Grampus griseus; kidney; kidney injury; Kogia; Kupffer cell; Lagenodelphis hosei; liver; liver cell; liver injury; male; mass spectrometry; metabolism; nonhuman; quantitative analysis; silver deposition; Stenella attenuata; water contamination; animal; Cetacea; environmental monitoring; Pacific Ocean; water pollutant; Cetacea; Rattus norvegicus; Animals; Cetacea; Environmental Monitoring; Liver; Male; Metal Nanoparticles; Pacific Ocean; Silver; Water Pollutants, Chemical |
Appears in Collections: | 分子暨比較病理生物學研究所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.