https://scholars.lib.ntu.edu.tw/handle/123456789/573273
標題: | Lysophosphatidic acid and hematopoiesis: From microenvironmental effects to intracellular signaling | 作者: | Lin K.-H Chiang J.-C Ho Y.-H Yao C.-L Lee H. HSIN-YU LEE |
關鍵字: | ADAM12 protein; amino acid receptor blocking agent; bone morphogenetic protein; erythroid kruppel like factor; G protein coupled receptor; glycerol 3 phosphate acyltransferase; leukemia inhibitory factor; lysophosphatidic acid; lysophosphatidic acid receptor; lysophosphatidic acid receptor agonist; lysophosphatidic acid receptor antagonist; mitogen activated protein kinase; phospholipase A; reactive oxygen metabolite; stromal cell derived factor 1; transcription factor; transcription factor Fli 1; transcription factor GATA; transcription factor GATA 1; transcription factor PU 1; transcription factor RUNX1; unclassified drug; lysophosphatidic acid; lysophosphatidic acid receptor; lysophospholipid; transcription factor; anemia; bone marrow stroma cell; cell differentiation; cell interaction; cell metabolism; cell migration; cell proliferation; chromatin immunoprecipitation; DNA sequence; embryo development; embryonic stem cell; endoplasmic reticulum; endosteal niche; fibrosing alveolitis; gene knockout; hematologic disease; hematopoiesis; hematopoietic stem cell; human; induced pluripotent stem cell; intracellular signaling; mesenchymal stem cell; microenvironment; nervous system development; neural stem cell; nonhuman; perivascular niche; protein expression; protein interaction; Review; signal transduction; stem cell niche; stem cell transplantation; anemia; animal; hematopoiesis; lipidomics; metabolism; physiology; tumor microenvironment; Anemia; Animals; Cellular Microenvironment; Hematopoiesis; Hematopoietic Stem Cells; Humans; Lipidomics; Lysophospholipids; Receptors, Lysophosphatidic Acid; Signal Transduction; Transcription Factors | 公開日期: | 2020 | 卷: | 21 | 期: | 6 | 來源出版物: | International Journal of Molecular Sciences | 摘要: | Vertebrate hematopoiesis is a complex physiological process that is tightly regulated by intracellular signaling and extracellular microenvironment. In recent decades, breakthroughs in lineage-tracing technologies and lipidomics have revealed the existence of numerous lipid molecules in hematopoietic microenvironment. Lysophosphatidic acid (LPA), a bioactive phospholipid molecule, is one of the identified lipids that participates in hematopoiesis. LPA exhibits various physiological functions through activation of G-protein-coupled receptors. The functions of these LPARs have been widely studied in stem cells, while the roles of LPARs in hematopoietic stem cells have rarely been examined. Nonetheless, mounting evidence supports the importance of the LPA-LPAR axis in hematopoiesis. In this article, we have reviewed regulation of hematopoiesis in general and focused on the microenvironmental and intracellular effects of the LPA in hematopoiesis. Discoveries in these areas may be beneficial to our understanding of blood-related disorders, especially in the context of prevention and therapy for anemia. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082018571&doi=10.3390%2fijms21062015&partnerID=40&md5=821c0a24772fe24487e8e05cf8b03816 https://scholars.lib.ntu.edu.tw/handle/123456789/573273 |
ISSN: | 16616596 | DOI: | 10.3390/ijms21062015 | SDG/關鍵字: | ADAM12 protein; amino acid receptor blocking agent; bone morphogenetic protein; erythroid kruppel like factor; G protein coupled receptor; glycerol 3 phosphate acyltransferase; leukemia inhibitory factor; lysophosphatidic acid; lysophosphatidic acid receptor; lysophosphatidic acid receptor agonist; lysophosphatidic acid receptor antagonist; mitogen activated protein kinase; phospholipase A; reactive oxygen metabolite; stromal cell derived factor 1; transcription factor; transcription factor Fli 1; transcription factor GATA; transcription factor GATA 1; transcription factor PU 1; transcription factor RUNX1; unclassified drug; lysophosphatidic acid; lysophosphatidic acid receptor; lysophospholipid; transcription factor; anemia; bone marrow stroma cell; cell differentiation; cell interaction; cell metabolism; cell migration; cell proliferation; chromatin immunoprecipitation; DNA sequence; embryo development; embryonic stem cell; endoplasmic reticulum; endosteal niche; fibrosing alveolitis; gene knockout; hematologic disease; hematopoiesis; hematopoietic stem cell; human; induced pluripotent stem cell; intracellular signaling; mesenchymal stem cell; microenvironment; nervous system development; neural stem cell; nonhuman; perivascular niche; protein expression; protein interaction; Review; signal transduction; stem cell niche; stem cell transplantation; anemia; animal; hematopoiesis; lipidomics; metabolism; physiology; tumor microenvironment; Anemia; Animals; Cellular Microenvironment; Hematopoiesis; Hematopoietic Stem Cells; Humans; Lipidomics; Lysophospholipids; Receptors, Lysophosphatidic Acid; Signal Transduction; Transcription Factors |
顯示於: | 生命科學系 |
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