https://scholars.lib.ntu.edu.tw/handle/123456789/573709
標題: | Magnetic Nanoparticle Images and Assaying Biomarkers via the Magnetic Relaxation of Biofunctionalized Nanoparticles Associated with Biotargets | 作者: | Wang L.-M., Yang T.-W., Wang C.-Y., Shen D., Chen J.-M., Chen K.-L., Liao S.-H. LI-MIN WANG |
關鍵字: | Association reactions; Biomarkers; High resolution transmission electron microscopy; Iron oxides; Magnetic force microscopy; Magnetic moments; Magnetic relaxation; Magnetite; Nanoparticles; Saturation magnetization; Transmission electron microscopy; Alphafetoprotein (AFP); Biofunctionalized nanoparticles; Inter-particle interaction; Iron oxide nanoparticle; Magnetic force microscopies (MFM); Magnetic nano-particles; Measurements of; Sensitivity limit; Nanomagnetics | 公開日期: | 2019 | 卷: | 19 | 期: | 20 | 起(迄)頁: | 9004-9009 | 來源出版物: | IEEE Sensors Journal | 摘要: | This paper presents a novel assay of biomarkers consisting of alpha-fetaprotein (AFP) via the measurements of saturation magnetization and magnetic relaxation. The biofunctionalized magnetic nanoparticles (BMNs) were anti-alpha-fetaprotein (antiAFP) coated onto dextran-coated iron oxide nanoparticles, labeled as Fe3O4-antiAFP, and then conjugated with AFP biotargets. After a complete conjugation of AFP and Fe3O4-antiAFP, the BMNs were dried for magnetic measurements. Magnetic nanoparticle images were obtained from magnetic force microscopy with details regarding the transmission electron microscopy images. Findings show that the saturation magnetization Ms increases with a rise in the associated AFP concentration and the magnetic relaxation time τ also shows a rapid increase when the concentration of AFP is lower than 0.2 ppm. Thus, we demonstrate a sensitive platform for detecting biomarkers by characterizing Ms and τ with a sensitivity limit of 0.03-ppm AFP. The results can be attributed to the interparticle interactions and the N?el motion of magnetic moments in BMNs. ? 2001-2012 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058065882&doi=10.1109%2fJSEN.2018.2884893&partnerID=40&md5=232dccb5cc445c3a62924bfbd269f36f https://scholars.lib.ntu.edu.tw/handle/123456789/573709 |
ISSN: | 1530437X | DOI: | 10.1109/JSEN.2018.2884893 |
顯示於: | 物理學系 |
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