NP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patients
Journal
Frontiers in endocrinology
Journal Volume
12
Date Issued
2021
Author(s)
Abstract
Somatic KCNJ5 mutation occurs in half of unilateral primary aldosteronism (PA) and is associated with more severe phenotype. Mutation status can only be identified by tissue sample from adrenalectomy. NP-59 adrenal scintigraphy is a noninvasive functional study for disease activity assessment. This study aimed to evaluate the predictive value of NP-59 adrenal scintigraphy in somatic KCNJ5 mutation among PA patients who received adrenalectomy.
Subjects
KCNJ5; NP-59 adrenal scintigraphy; mutation prediction; primary aldosteronism; semiquantification
SDGs
Other Subjects
dexamethasone; macrolide; adrenal scintiscanning; adrenalectomy; adult; Article; computer assisted tomography; dexamethasone suppression test; diagnostic test accuracy study; disease activity; DNA sequencing; female; gene mutation; human; kcnj5 gene; major clinical study; male; phenotype; primary hyperaldosteronism; retrospective study; sensitivity and specificity; single photon emission computed tomography
Type
journal article