https://scholars.lib.ntu.edu.tw/handle/123456789/575791
標題: | Tandem Quantification of Multiple Carbohydrates in Saliva Using Surface-Enhanced Raman Spectroscopy | 作者: | Lin D Yang S.-W Hsieh C.-L Hsu K.-J Gong T Wu Q Qiu S Feng S Kong K.V. KIEN-VOON KONG |
關鍵字: | Diagnosis; Glucose; Light transmission; Raman spectroscopy; Detection range; Disease diagnosis; Health informations; Human body fluids; Multiplex detections; Physiological concentrations; Quantitative detection; Surface enhanced Raman spectroscopy; Body fluids; carbohydrate; fructose; glucose; human; Raman spectrometry; saliva; Carbohydrates; Fructose; Glucose; Humans; Saliva; Spectrum Analysis, Raman | 公開日期: | 2021 | 卷: | 6 | 期: | 3 | 起(迄)頁: | 1240-1247 | 來源出版物: | ACS Sensors | 摘要: | The detection of carbohydrates in human body fluids is critical for disease diagnosis and healthy monitoring. Despite recent advances in glucose sensing, multiplex detection of different carbohydrates within a single assay that is capable of efficiently providing richer health information remains challenging. Herein, we report a versatile surface-enhanced Raman spectroscopy-based platform for the quantitative detection of monosaccharides (glucose, fructose, and galactose) in one test using a displace-and-trap mechanism. Moreover, due to the use of multiple optical interference-free (1800-2200 cm-1) signal-independent Raman probes, the detection range of this platform (0.125-7 mg/dL) perfectly covers physiological concentrations, enabling the quantitative detection of glucose and galactose in clinical human saliva samples. This work provides a noninvasive and high-efficiency potential tool for the screening of clinical diabetes and other carbohydrate-related diseases. ? |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101716626&doi=10.1021%2facssensors.0c02533&partnerID=40&md5=5a1a1afdad04fd49730ac9d234dfc4cf https://scholars.lib.ntu.edu.tw/handle/123456789/575791 |
ISSN: | 23793694 | DOI: | 10.1021/acssensors.0c02533 | SDG/關鍵字: | Diagnosis; Glucose; Light transmission; Raman spectroscopy; Detection range; Disease diagnosis; Health informations; Human body fluids; Multiplex detections; Physiological concentrations; Quantitative detection; Surface enhanced Raman spectroscopy; Body f |
顯示於: | 化學系 |
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