https://scholars.lib.ntu.edu.tw/handle/123456789/575794
標題: | Advanced Near-Infrared Light-Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy | 作者: | Chien Y.-H Chan K.K Anderson T Kong K.V Ng B.K Yong K.-T. KIEN-VOON KONG |
關鍵字: | carbon nanoparticle; dichalcogenide; gold nanorod; lanthanide; metal oxide; nanomaterial; phosphorus; transition dichalcogenide derivative; transition element; unclassified drug; upconversion nanoparticle; biocompatibility; cancer chemotherapy; cancer gene therapy; cancer therapy; chemical modification; drug delivery system; drug release; drug synthesis; gene delivery system; human; light scattering; luminescence; nanotechnology; near infrared spectroscopy; nonhuman; photoacoustics; photodynamic therapy; photothermal therapy; polymerization; priority journal; Review; surface area; surface plasmon resonance; theranostic nanomedicine; treatment outcome | 公開日期: | 2019 | 卷: | 2 | 期: | 3 | 來源出版物: | Advanced Therapeutics | 摘要: | Cancer is one of the leading causes of death. Despite the huge progress in the field of cancer drugs and therapies, the treatment outcome is still bleak for most cancer patients. Nanotechnology has revolutionized cancer therapeutics. By using nano-sized particles as delivery systems, therapeutic biomolecules are transported efficiently to the target sites. Moreover, these particles are designed to carry out multiple cancer treatments simultaneously. Near-infrared (NIR) light-responsive nanomaterials have gained much attention as NIR light has a greater penetration depth, minimal phototoxicity, lower autofluorescence, and reduced light scattering. Among the available NIR light-responsive nanomaterials, gold nanorods, upconversion nanoparticles, carbon dots, transition metal dichalcogenide, metal oxides, black phosphorus, and polymeric nanomaterials have become attractive options owing to their excellent optical properties, ease of synthesis and modification, outstanding photodynamic and photothermal conversion properties, and most importantly, favorable toxicity level and biocompatibility which are prerequisites for biological applications. In this review, the outstanding properties, synthesis, and surface functionalization of the aforementioned NIR light-responsive nanomaterials are introduced in detail. Recent advances of these nanomaterials for various cancer treatment modalities are summarized to highlight their versatility and potential in cancer theranostics. Finally, a perspective is proposed on future research directions and their clinical translation. ? 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103744391&doi=10.1002%2fadtp.201800090&partnerID=40&md5=c6344f1b9dc3bd0d9c237804828bfd24 https://scholars.lib.ntu.edu.tw/handle/123456789/575794 |
ISSN: | 23663987 | DOI: | 10.1002/adtp.201800090 | SDG/關鍵字: | carbon nanoparticle; dichalcogenide; gold nanorod; lanthanide; metal oxide; nanomaterial; phosphorus; transition dichalcogenide derivative; transition element; unclassified drug; upconversion nanoparticle; biocompatibility; cancer chemotherapy; cancer gene therapy; cancer therapy; chemical modification; drug delivery system; drug release; drug synthesis; gene delivery system; human; light scattering; luminescence; nanotechnology; near infrared spectroscopy; nonhuman; photoacoustics; photodynamic therapy; photothermal therapy; polymerization; priority journal; Review; surface area; surface plasmon resonance; theranostic nanomedicine; treatment outcome |
顯示於: | 化學系 |
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