Social adjustment and family function after drug switch from IR-methylphenidate to OROS-methylphenidate in patients with attention-deficit/hyperactivity disorder
Journal
Neuropsychiatric Disease and Treatment
Journal Volume
14
Pages
2783-2791
Date Issued
2018
Author(s)
Chou W.-J.
Wang L.-J.
Lin C.-H.
Liang S.-Y.
Chen V.C.-H.
Hou Y.-M.
Huang R.-R.
Chou M.-C.
Ho C.-P.
Lai M.-C.
Abstract
Purpose: This prospective, single-arm, open-label, 8-week, multicenter study investigated the effectiveness of switching from immediate-release methylphenidate (IR-MPH) to osmotic controlled-release methylphenidate (OROS-MPH) in patients with attention-deficit/hyperactivity disorder (ADHD). Patients and methods: Overall, 296 patients with ADHD (mean age: 9.5 years) already on IR-MPH treatment were enrolled. Upon enrollment, a flexible dose of OROS-MPH was administered, replacing IR-MPH. Patients were assessed at baseline and weeks 2, 4, and 8 using the Swanson, Nolan, and Pelham version IV scale (SNAP-IV) and the Clinical Global Impression for ADHD symptoms. The Social Adjustment Inventory for Children and Adolescents assessed social functions, and the Chinese Health Questionnaire (CHQ) and Family Adaptation, Partnership, Growth, Affection, and Resolve evaluated parental and family functions. Results: Switching from IR-MPH to OROS-MPH yielded significant improvements in all ADHD symptoms, as rated by parents, teachers (SNAP-IV), and study investigators (Clinical Global Impression). CHQ scores and all Social Adjustment Inventory for Children and Adolescents subscores except spare time scores improved significantly. Patients with poor IR-MPH adherence had greater improvements in teacher-rated SNAP-IV and mothers’ mental health (CHQ) after switching. Conclusion: Switching from IR-MPH to OROS-MPH improved patients’ behavioral ADHD symptoms and social adjustment, and mental health of patients’ mothers. This was most evident in patients who previously exhibited poor IR-MPH adherence. ? 2018 Chou et al.
Subjects
ADHD; Central nervous system stimulant; Drug adherence; Family; Social adjustment
SDGs
Other Subjects
methylphenidate; abdominal pain; adolescent; Article; attention deficit disorder; child; Chinese Health Questionnaire; clinical effectiveness; Clinical Global Impression scale; controlled clinical trial; controlled drug release; controlled study; decreased appetite; dizziness; drowsiness; drug release; drug safety; drug substitution; drug withdrawal; family functioning; female; headache; human; immediate drug release; insomnia; major clinical study; male; medication compliance; multicenter study; nausea; osmotic controlled drug release; patient assessment; patient compliance; school child; scoring system; social adaptation; Social Adjustment Inventory for Children and Adolescent; social status; stomach pain; Swanson Nolan and Pelham version IV scale; treatment duration; treatment outcome
Type
journal article