https://scholars.lib.ntu.edu.tw/handle/123456789/576070
標題: | An injectable, self-healing phenol-functionalized chitosan hydrogel with fast gelling property and visible light-crosslinking capability for 3D printing | 作者: | Liu Y Wong C.-W SHU-WEI CHANG SHAN-HUI HSU |
關鍵字: | chitosan; phenol; bioprinting; hydrogel; light; three dimensional printing; tissue engineering; Bioprinting; Chitosan; Hydrogels; Light; Phenol; Printing, Three-Dimensional; Tissue Engineering | 公開日期: | 2021 | 卷: | 122 | 起(迄)頁: | 211-219 | 來源出版物: | Acta Biomaterialia | 摘要: | Self-healing hydrogels attract broad attention as cell/drug carriers for direct injection into damaged tissues or as bioinks for three-dimensional (3D) printing of tissue-like constructs. For application in 3D printing, the self-healing hydrogels should maintain the steady rheological properties during printing process, and be further stabilized by secondary post-printing crosslinking. Here, a chitosan self-healing hydrogel is developed for injectable hydrogel and printable ink using phenol-functionalized chitosan and dibenzaldehyde-terminated telechelic poly(ethylene glycol). Phenol functionalization of chitosan can introduce unique interaction that allows the hydrogel to possess fast gelling rate, good self-healing ability, and long-range critical gel behavior, as well as secondary visible light-crosslinking capability. The hydrogel is easily pre-formed in a syringe and extruded through a 26-gauge needle to produce a continuous and stackable filament. The cell-laden hydrogel is successfully printed into a 3D construct. Moreover, the hydrogel is developed for modular 3D printing, where hydrogel modules (LEGO-like building blocks) are individually printed and assembled into an integrated construct followed by secondary visible light-crosslinking. The versatile phenol-functionalized chitosan self-healing hydrogel will open up numerous potential applications, particularly in 3D bioprinting and modular 3D bioprinting. ? 2021 Acta Materialia Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099608566&doi=10.1016%2fj.actbio.2020.12.051&partnerID=40&md5=03df18606510352be48bfcd6c592b183 https://scholars.lib.ntu.edu.tw/handle/123456789/576070 |
ISSN: | 17427061 | DOI: | 10.1016/j.actbio.2020.12.051 |
顯示於: | 土木工程學系 |
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