https://scholars.lib.ntu.edu.tw/handle/123456789/576122
標題: | Effects of different electrodes used in bone-guided extracochlear implants on electrical stimulation of auditory nerves in guinea pigs | 作者: | Liu C.-H Lu Y.-S Chen P.-C Lee C.-F. CHIEN-HAO LIU |
關鍵字: | gold; iridium; iridium oxide; platinum; unclassified drug; animal experiment; Article; biocompatibility; cochlear nerve; cyclic voltammetry; electrostimulation; guinea pig; in vivo study; nonhuman | 公開日期: | 2021 | 卷: | 33 | 期: | 1 | 起(迄)頁: | 42-48 | 來源出版物: | Tzu Chi Medical Journal | 摘要: | Objective: Conventional cochlear implants provide patients who are deaf with hearing via electrical intracochlear stimulations. Stimulation electrodes are inserted into the cochlea through a cochleostomy or round window membrane (RWM) approach. However, these methods might induce cochlear ossificans and loss of residual hearing by damaging inner ear structures. To avoid an invasive electrode insertion, we developed a novel bone-guided extracochlear implant that stimulated the auditory nerves between the cochlear bones and the RWM to prevent cochlea damage. Power consumption plays an important role in wireless implantable electronic devices. Therefore, we aimed to investigate the effects of different electrodes on the stimulating threshold currents of the auditory nerve and the power consumption of bone-guided extracochlear implants using a commercial stimulator. Materials and Methods: Inert aurum (Au) electrodes were compared with biocompatible platinum (Pt) and iridium oxide (IrOx) electrodes in practical implantable applications. IrOxelectrodes were used for their high-charge storage capacity, low impedance, and biocompatibility. The electrodes were fabricated via sputtering and were experimentally characterized with cyclic voltammetry and then examined using in vivo tests. Results: Based on electrical auditory brainstem responses, IrOxelectrodes yielded lower acoustic nerve-stimulating threshold currents (132 μA) compared with Au electrodes (204 μA). IrOxelectrodes also had a lower acoustic nerve stimulating threshold current (132 μA) compared with Pt electrodes (168 μA). Conclusion: As expected, IrOxelectrodes were beneficial in the development of multielectrode bone-guided extracochlear implants, with the lowest acoustic nerve-stimulating threshold and current consumptions compared with Au and Pt electrodes. ? 2021 Tzu Chi Medical Journal | Published by Wolters Kluwer - Medknow. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099305699&doi=10.4103%2ftcmj.tcmj_46_20&partnerID=40&md5=c67a4c1e59957aadd3f849f6bf816a41 https://scholars.lib.ntu.edu.tw/handle/123456789/576122 |
ISSN: | 10163190 | DOI: | 10.4103/tcmj.tcmj_46_20 |
顯示於: | 機械工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。