|Title:||Long-term in vitro degradation and in vivo evaluation of resorbable bioceramics||Authors:||Chen Y.-C
|Keywords:||Bioceramics; Biodegradation; Bone; Calcium compounds; Defects; Degradation; Sintering; Sulfur compounds; Calcium sulfate; Degradation rate; Degradation test; Distal femurs; Initial weights; Phosphate-buffered solutions; Recovery time; Strong dependences; Strontium compounds; bioceramics; calcium sulfate; phosphate buffered saline; strontium; animal experiment; animal model; animal tissue; Article; body weight change; body weight loss; bone defect; controlled study; degradation; distal femur; fracture healing; histology; in vitro study; in vivo study; micro-computed tomography; nonhuman; priority journal; rat; X ray diffraction||Issue Date:||2021||Journal Volume:||32||Journal Issue:||1||Source:||Journal of Materials Science: Materials in Medicine||Abstract:||
An essential criterion for the selection of resorbable bioceramics is their ability to degrade inside human body within a reasonable time frame. Furthermore, if the bioceramic can release beneficial ions, such as strontium, as it degrades, recovery time might be shortened. The present study demonstrates that strontium-containing calcium sulfate (Sr,Ca)SO4 can fulfill these criteria. A long-term in vitro degradation analysis for 12 weeks using sintered (Sr,Ca)SO4 discs in phosphate buffered solution (PBS) was conducted. The sintered (Sr,Ca)SO4 disc was then implanted into defects in the distal femur of rats. The degradation rate of (Sr,Ca)SO4 discs showed a strong dependence on the Sr content. Similar results were observed between the long-term in vitro degradation analysis and the in vivo evaluation. The sintered (3.8%Sr,Ca)SO4 disc lost more than 80% of its initial weight after soaking in PBS with shaking at 37 °C for 12 weeks. After 12 weeks in vivo, the remaining volume of the (3.8%Sr,Ca)SO4 disc within the bone defect was ~25%. Over the same time period, new bone was formed at a relative volume of 40%. This study demonstrates the potential of (Sr,Ca)SO4 bioceramic, and the benefits of using a long-term degradation test during the evaluation of resorbable bioceramics. ? 2021, The Author(s).
|Appears in Collections:||材料科學與工程學系|
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