A microfluidic platform for developing a vascularized microtissue based on filtration and reabsorption process
Journal
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Journal Volume
3
Pages
1582-1585
Date Issued
2018
Author(s)
Abstract
This paper describes a microfluidic platform for developing a vascularized microtissue based on filtration and reabsorption process found in a capillary system. The design concept is an analogy between microfluidic channel and electric circuit. A long microchannel is used to connect a cell culture chamber at two different locations to create the filtration and reabsorption effect. Interstitial flow is generated inside the tissue chamber that mimics capillary exchange process. Experimental results demonstrate that using this technique vasculogenic process can be induced and a vessel network can be developed. Copyright ? (2018) by Chemical and Biological Microsystems Society. All rights reserved.
Subjects
Cell culture; Filtration; Capillary system; Exchange process; Interstitial flow; Microfluidic channel; Microfluidic platforms; Microtissue; Reabsorption; Vasculogenesis; Microfluidics
Type
conference paper