https://scholars.lib.ntu.edu.tw/handle/123456789/577136
標題: | Enhancement of neurite outgrowth by warming biomaterial ultrasound treatment | 作者: | Chen J.-C Su C.-M Chen G.-S Lai C.-C Chen C.-Y Lin K.M.-C Lin F.-H Dong G.-C. Lin, Feng-Huei |
關鍵字: | acetylcholinesterase; biomaterial; magnetite nanoparticle; polycaprolactone; tubulin; acetylcholinesterase; biomaterial; animal cell; Article; cell viability; controlled study; cytotoxicity; differential scanning calorimetry; enzyme activity; in vitro study; mouse; nerve cell lesion; neurite outgrowth; Neuro-2a cell line; nonhuman; scanning electron microscopy; thermal conductivity; thermostability; ultrasound therapy; warming; animal; cell line; cell survival; metabolism; nerve cell; neurite outgrowth; radiation response; rat; temperature; ultrasound; Acetylcholinesterase; Animals; Biocompatible Materials; Cell Line; Cell Survival; Neuronal Outgrowth; Neurons; Rats; Temperature; Ultrasonic Waves | 公開日期: | 2020 | 卷: | 21 | 期: | 6 | 來源出版物: | International Journal of Molecular Sciences | 摘要: | Ultrasound is a method for enhancing neurite outgrowth because of its thermal effect. In order to reach the working temperature to enhance neurite outgrowth, long-time treatment by ultrasound is necessary, while acknowledging that the treatment poses a high risk of damaging nerve cells. To overcome this problem, we developed a method that shortens the ultrasonic treatment time with a warming biomaterial. In this study, we used Fe3O4 nanoparticle-embedded polycaprolactone (PCL) as a sonosensitized biomaterial, which has an excellent heating rate due to its high acoustic attenuation. With this material, the ultrasonic treatment time for enhancing neurite outgrowth could be effectively shortened. Ultrasonic treatment could also increase neuronal function combined with the warming biomaterial, with more promoter neuronal function than only ultrasound. Moreover, the risk of overexposure can be avoided by the use of the warming biomaterial by reducing the ultrasonic treatment time, providing better effectiveness. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380009&doi=10.3390%2fijms21062236&partnerID=40&md5=4b492d4264d0d2050299ac53d4732dc4 https://scholars.lib.ntu.edu.tw/handle/123456789/577136 |
ISSN: | 16616596 | DOI: | 10.3390/ijms21062236 |
顯示於: | 醫學工程學研究所 |
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