https://scholars.lib.ntu.edu.tw/handle/123456789/577164
標題: | Bovine Serum Albumin (BSA)/polyacrylonitrile (PAN) biohybrid nanofibers coated with a biomineralized calcium deficient hydroxyapatite (HA) shell for wound dressing | 作者: | Homaeigohar S Tsai T.-Y Zarie E.S Elbahri M Young T.-H Boccaccini A.R. Young, Tai-Horng |
關鍵字: | Body fluids; Calcium; Cell culture; Fibroblasts; Hydroxyapatite; Mammals; Natural polymers; Biofunctional; Biological characteristic; Bovine serum albumins; Calcium deficient hydroxyapatite; Industrial polymers; Polyacrylonitrile (PAN); Simulated body fluids; Wound dressings; Nanofibers; acrylic acid resin; bovine serum albumin; calcium; hydroxyapatite; nanofiber; polyacrylonitrile; bandage; Acrylic Resins; Bandages; Calcium; Durapatite; Nanofibers; Serum Albumin, Bovine | 公開日期: | 2020 | 卷: | 116 | 來源出版物: | Materials Science and Engineering C | 摘要: | Here, for the first time, a nanofibrous (NF) wound dressing comprising biomineralized polyacrylonitrile (PAN) nanofibers is developed. In contrast to the majority of the currently available nanofibrous wound dressings that are based on natural polymers, PAN is a synthetic, industrial polymer, which has been rarely considered for this purpose. PAN NFs are first hydrolyzed to allow for tethering of biofunctional agents (here Bovine Serum Albumin (BSA)). Later, the biofunctionlized PAN NFs are biomineralized by immersion in simulated body fluid (SBF). As a result, core-shell, calcium deficient hydroxyapatite (HA)/BSA/PAN nanofibers form, that are mechanically stronger (elastic modulus; 8.5 vs. 6 MPa) compared to the untreated PAN NFs. The biomineralized PAN NFs showed promising bioactivity as reflected in the cell biology tests with fibroblast and keratinocyte cells. Hs68 fibroblasts and HaCat keratinocytes were found to be more viable in the presence of the biomineralized NFs than when they were co-cultured with the neat PAN NFs. Such mechanical and biological characteristics of the biomineralized PAN NFs are favorable for wound dressing applications. ? 2020 The Authors |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087687702&doi=10.1016%2fj.msec.2020.111248&partnerID=40&md5=54ca64e45c8bf5c99d2e31b6e0e2f629 https://scholars.lib.ntu.edu.tw/handle/123456789/577164 |
ISSN: | 9284931 | DOI: | 10.1016/j.msec.2020.111248 |
顯示於: | 醫學工程學研究所 |
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