Formation of highly elastomeric and property-tailorable poly(glycerol sebacate)-: Co -poly(ethylene glycol) hydrogels through thiol-norbornene photochemistry
Journal
Biomaterials Science
Journal Volume
8
Journal Issue
17
Pages
4728-4738
Date Issued
2020
Author(s)
Abstract
Poly(glycerol sebacate) (PGS) is a synthetic biorubber that presents good biocompatibility, excellent elasticity and desirable mechanical properties for biomedical applications; however, the inherent hydrophobicity and traditional thermal curing of PGS restrict its use in the fabrication of hydrogels for advanced bioapplications. Here, we designed a new class of hydrophilic PGS-based copolymers that allow hydrogel formation through thiol-norbornene chemistry. Poly(glycerol sebacate)-co-polyethylene glycol (PGS-co-PEG) macromers were synthesized through a stepwise polycondensation reaction, and then the norbornene functional groups were introduced to the PGS-co-PEG structure to form norbornene-functionalized PGS-co-PEG (Nor_PGS-co-PEG). Nor_PGS-co-PEG macromers can be crosslinked using dithiols to prepare hydrogels in the presence of light and photoinitiators. The mechanical, swelling and degradation properties of Nor_PGS-co-PEG hydrogels can be controlled by altering the crosslinker amount. In particular, the elongation of Nor_PGS-co-PEG hydrogels can be modulated up to 950%. Nor_PGS-co-PEG can be processed using electrospinning and 3D printing techniques to generate microfibrous scaffolds and printed structures, respectively. In addition, the cytocompatibility of Nor_PGS-co-PEG was also demonstrated using in vitro cellular viability studies. These results indicate that Nor_PGS-co-PEG is a promising biomaterial with definable properties for scaffold manufacturing, presenting a great potential for biomedical applications. ? 2020 The Royal Society of Chemistry.
Subjects
3D printers; Aliphatic compounds; Biocompatibility; Crosslinking; Glycerol; Medical applications; Polyethylene glycols; Scaffolds (biology); Biomedical applications; Cellular viability; Hydrogel formation; Polies (glycerolsebacate); Poly(ethylene glycol) hydrogel; Poly(glycerol sebacate); Polycondensation reactions; Scaffold manufacturing; Hydrogels; biomaterial; copolymer; dithiol derivative; elastomer; functional group; hydrogel; macrogol; molecular scaffold; norbornene derivative; photoinitiator; sebacic acid; biomaterial; decanoic acid derivative; glycerol; macrogol; norbornane derivative; poly(glycerol-sebacate); polymer; thiol derivative; Article; biocompatibility; cell viability; controlled study; cross linking; degradation; electrospinning; hydrophilicity; in vitro study; light; photochemistry; polymerization; priority journal; synthesis; three dimensional printing; elasticity; hydrogel; photochemistry; Biocompatible Materials; Decanoates; Elasticity; Glycerol; Hydrogels; Norbornanes; Photochemistry; Polyethylene Glycols; Polymers; Sulfhydryl Compounds
SDGs
Type
journal article