https://scholars.lib.ntu.edu.tw/handle/123456789/577304
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YUN-LIANG CHANG | en_US |
dc.contributor.author | Hsieh, Chia-Ying | en_US |
dc.contributor.author | Yeh, Chao-Yuan | en_US |
dc.contributor.author | CHIH-HAO CHANG | en_US |
dc.contributor.author | FENG-HUEI LIN | en_US |
dc.date.accessioned | 2021-08-09T07:19:28Z | - |
dc.date.available | 2021-08-09T07:19:28Z | - |
dc.date.issued | 2021-07-14 | - |
dc.identifier.issn | 2072-666X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/577304 | - |
dc.description.abstract | Bone defects of orthopedic trauma remain a challenge in clinical practice. Regarding bone void fillers, besides the well-known osteoconductivity of most bone substitutes, osteoinductivity has also been gaining attention in recent years. It is known that stromal cell-derived factor-1 (SDF-1) can recruit mesenchymal stem cells (MSCs) in certain circumstances, which may also play an important role in bone regeneration. In this study, we fabricated a gelatin/hyaluronate (Gel/HA) copolymer mixed with hydroxyapatite (HAP) and SDF-1 to try and enhance bone regeneration in a bone defect model. After material characterization, these Gel/HA-HAP and Gel/HA-HAP-SDF-1 composites were tested for their biocompatibility and ability to recruit MSCs in vitro. A femoral condyle bone defect model of rats was used for in vivo studies. For the assessment of bone healing, micro-CT analysis, second harmonic generation (SHG) imaging, and histology studies were performed. As a result, the Gel/HA-HAP composites showed no systemic toxicity to rats. Gel/HA-HAP composite groups both showed better bone generation compared with the control group in an animal study, and the composite with the SDF-1 group even showed a trend of faster bone growth compared with the composite without SDF-1 group. In conclusion, in the management of traumatic bone defects, Gel/HA-HAP-SDF-1 composites can be a feasible material for use as bone void fillers. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Micromachines | en_US |
dc.subject | biomaterial; bone defect; bone regeneration; gelatin; hyaluronate; hydroxyapatite; mesenchymal stem cells; tissue engineering | en_US |
dc.title | Fabrication of Stromal Cell-Derived Factor-1 Contained in Gelatin/Hyaluronate Copo006Cymer Mixed with Hydroxyapatite for Use in Traumatic Bone Defects | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/mi12070822 | - |
dc.identifier.pmid | 34357232 | - |
dc.identifier.scopus | 2-s2.0-85111139348 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85111139348 | - |
dc.relation.journalvolume | 12 | en_US |
dc.relation.journalissue | 7 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Orthopedic Surgery-NTUH | - |
crisitem.author.dept | Orthopedic Surgery | - |
crisitem.author.dept | National Taiwan University Hospital Jin-shan Branch | - |
crisitem.author.dept | Orthopedic Surgery-NTUH | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.orcid | 0000-0001-5470-3367 | - |
crisitem.author.orcid | 0000-0001-9794-0610 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 醫學系 |
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