|Title:||Close correlation between the ankle-brachial index and symptoms of depression in hemodialysis patients||Authors:||Jong I.-C.
|Keywords:||Ankle-brachial index; Beck depression inventory; Depression; Hemodialysis||Issue Date:||2017||Publisher:||Springer Netherlands||Journal Volume:||49||Journal Issue:||8||Start page/Pages:||1463-1470||Source:||International Urology and Nephrology||Abstract:||
Background: As both of peripheral arterial disease (PAD) and depression carried a poor prognosis in patients on maintenance hemodialysis (MHD), we investigated the correlation between the ankle-brachial index (ABI), an indicator of subclinical PAD, and symptoms of depression in patients on MHD. Methods: One hundred and twenty-nine patients on MHD (75 males and 54 females, mean age 64.8?±?12?years) were enrolled in this cross-sectional study, which aimed at evaluating the relationship between symptoms of depression and ABI. Demographic as well as clinical and laboratory variables including status of diabetes, chronic hepatitis C infection, dialysis duration, Charlson comorbidity index (CCI), plasma levels of albumin, C-peptide, insulin, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), adiponectin, and lipid profile were obtained. The self-administered beck depression inventory (BDI) was used to determine the presence or absence of symptoms of depression, and depression was defined as a BDI score ≧14. Multivariable-adjusted linear regression models were constructed to confirm the independent association of biologic parameters of symptoms of depression. Significance was defined as P?0.05. Statistical analyses were performed using SPSS/Windows software (SPSS Science, v. 15.0, Chicago, IL). Results: The mode of multivariate analysis showed that diabetes (β?=?3.594; P?=?0.040), hepatitis C infection (β?=?4.057; P?=?0.008), levels of serum albumin (β?=??5.656; P?=?0.024), C-peptide (β?=??0.292; P?=?0.002), ABI (β?=??9.041; P?=?0.031), and Ln-transformed hsCRP were significantly associated with BDI. Conclusions: Hepatitis C infection, serum levels of albumin, C-peptide, and ABI levels were found to be correlated with BDI (P?0.05). ? 2017, The Author(s).
|ISSN:||0301-1623||DOI:||10.1007/s11255-017-1598-7||SDG/Keyword:||adiponectin; albumin; C peptide; C reactive protein; insulin; interleukin 6; C peptide; C reactive protein; serum albumin; adult; aged; albumin blood level; ankle brachial index; Article; Beck Depression Inventory; Charlson Comorbidity Index; chronic hepatitis C; controlled study; correlation analysis; cross-sectional study; demography; depression; diabetes mellitus; dialysis; drug self administration; female; hemodialysis patient; human; lipid analysis; major clinical study; male; multiple linear regression analysis; multivariate logistic regression analysis; symptomatology; treatment duration; blood; chronic kidney failure; depression; hemodialysis; hepatitis C; metabolism; middle aged; pathophysiology; peripheral occlusive artery disease; psychological rating scale; psychology; symptom assessment; Aged; Ankle Brachial Index; C-Peptide; C-Reactive Protein; Cross-Sectional Studies; Depression; Diabetes Mellitus; Female; Hepatitis C; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peripheral Arterial Disease; Psychiatric Status Rating Scales; Renal Dialysis; Serum Albumin; Symptom Assessment
|Appears in Collections:||醫學系|
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