https://scholars.lib.ntu.edu.tw/handle/123456789/578426
標題: | End stage renal disease is associated with development of dementia | 作者: | Hung P.-H. Yeh C.-C. Hsiao C.-Y. Sung P.-S. Muo C.-H. Sung F.-C. KUAN-YU HUNG Tsai K.-J. |
關鍵字: | Alzheimer's disease; Dementia; End stage renal disease; Gerotarget; Hemodialysis; Peritoneal dialysis | 公開日期: | 2017 | 出版社: | Impact Journals LLC | 卷: | 8 | 期: | 64 | 起(迄)頁: | 107348-107355 | 來源出版物: | Oncotarget | 摘要: | There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia. ? Hung et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037341187&doi=10.18632%2foncotarget.22458&partnerID=40&md5=fae369127d4a182186a97f29dce4045d https://scholars.lib.ntu.edu.tw/handle/123456789/578426 |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.22458 | SDG/關鍵字: | adult; Alzheimer disease; Article; cohort analysis; controlled study; dementia; disease association; end stage renal disease; female; hemodialysis; human; major clinical study; male; middle aged; multiinfarct dementia; peritoneal dialysis; risk factor; survival rate; Taiwan |
顯示於: | 醫學系 |
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