https://scholars.lib.ntu.edu.tw/handle/123456789/578501
標題: | Urothelial carcinoma in patients with advanced kidney disease: A 12-year retrospective cohort survey | 作者: | Hung P.-H. Shen C.-H. Tsai H.-B. Hsiao C.-Y. Chiang P.-C. Guo H.-R. KUAN-YU HUNG |
關鍵字: | Chronic kidney disease; End-stage renal disease; Survival; Taiwan; Urothelial carcinoma | 公開日期: | 2011 | 出版社: | Lippincott Williams and Wilkins | 卷: | 342 | 期: | 2 | 起(迄)頁: | 148-152 | 來源出版物: | American Journal of the Medical Sciences | 摘要: | Introduction: The goal of this study was to compare the clinical and pathological features of urothelial carcinoma (UC) identified in patients with end-stage renal disease (ESRD) and advanced-stage chronic kidney disease (CKD). The predictive value of CKD on patient mortality in these UC patients was also analyzed. Methods: From January 1997 to December 2008, 141 patients with pathologically proven UC with stage 4/5 CKD (predialysis) and patients with ESRD receiving long-term dialysis were identified under an institutional review board approval protocol. The medical records and survival outcome of these patients were reviewed. Results: A total of 141 UC patients with renal diseases (n = 97, 68.8%, of stage 4/5 CKD; n = 44, 31.2%, at dialysis) were enrolled. Patients with stage 4/5 CKD were significantly older, male gender, less anemic and more likely to have higher prevalence of diabetes mellitus (P < 0.05). We noticed a more significant increase in the frequency of high-stage UC (24.7% and 6.8%) and a larger tumor size (50.5% and 27.3%) in patients with stage 4/5 CKD, compared with patients with ESRD (P < 0.05). Old age at the time of dialysis initiation in patients with ESRD [hazard ratio (HR) = 1.121, P = 0.039], male gender (HR = 6.822, P = 0.016) and high-stage tumors (HR = 5.012, P = 0.008) in patients with stage 4/5 CKD were independent predictors of mortality from UC. Conclusions: Patients with stage 4/5 CKD had more aggressive histological UC patterns than did patients with ESRD. ? 2011 Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79961030929&doi=10.1097%2fMAJ.0b013e318223e800&partnerID=40&md5=de2c4e7d94a08c01e5f3f83da4345c69 https://scholars.lib.ntu.edu.tw/handle/123456789/578501 |
ISSN: | 0002-9629 | DOI: | 10.1097/MAJ.0b013e318223e800 | SDG/關鍵字: | creatinine; adult; anemia; cancer mortality; cancer survival; cause of death; chronic kidney disease; cohort analysis; controlled study; creatinine blood level; diabetes mellitus; disease course; female; hemodialysis; histopathology; human; human tissue; kidney biopsy; kidney failure; major clinical study; male; medical record review; retrospective study; review; transitional cell carcinoma; tumor volume |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。