|Title:||Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease||Authors:||FAN-CHI CHANG
|Issue Date:||2013||Journal Volume:||8||Journal Issue:||3||Start page/Pages:||e54668||Source:||PLoS ONE||Abstract:||
Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued by the relationship between albuminuria and angiopoietin-2. A total of 416 patients with CKD stages 3 to 5 were stratified by urine albumin-creatinine ratio as normoalbuminuria (<30 mg/g), microalbuminuria (30-300 mg/g), or macroalbuminuria (>300 mg/g). The levels of plasma angiopoietin-2 and vascular endothelial growth factor (VEGF) increased, and soluble Tie-2 decreased in the subgroups of albuminuria; whereas angiopoietin-1 did not change. Linear regression showed a positive correlation between urine albumin-creatinine ratio (ACR) and plasma angiopoietin-2 (correlation coefficient r = 0.301, 95% confidence interval 0.211-0.386, P<0.0001), but not between ACR and VEGF or soluble Tie-2. Multivariate linear regression analysis showed that plasma angiopoietin-2 was independently associated with ACR (P = 0.025). Furthermore, plasma angiopoietin-2 was positively correlated with high sensitive C-reactive protein (r = 0.114, 95% confidence interval 0.018-0.208, P = 0.020). In conclusion, plasma angiopoietin-2 was associated with albuminuria and markers of systemic microinflammation in CKD patients. Although previous evidence has shown that angiopoietin-2 destabilizes vasculature and induces inflammation in different scenarios, further study will be required to delineate the role of angiopoietin-2 in albuminuria and microinflammation in CKD patients. ? 2013 Chang et al.
|ISSN:||1932-6203||DOI:||10.1371/journal.pone.0054668||SDG/Keyword:||albumin; angiopoietin 2; angiopoietin receptor; C reactive protein; creatinine; vasculotropin; adult; aged; albuminuria; article; chronic kidney disease; cross-sectional study; disease association; female; human; inflammation; macroalbuminuria; major clinical study; male; microalbuminuria; microinflammation; protein blood level; Aged; Albuminuria; Angiopoietin-1; Angiopoietin-2; Biological Markers; C-Reactive Protein; Cardiovascular Diseases; Creatinine; Female; Glomerular Filtration Rate; Humans; Inflammation; Male; Middle Aged; Multivariate Analysis; Renal Insufficiency, Chronic; Vascular Endothelial Growth Factor A
|Appears in Collections:||醫學系|
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