https://scholars.lib.ntu.edu.tw/handle/123456789/579237
標題: | Emergence of T cell immunosenescence in diabetic chronic kidney disease | 作者: | Chiu, Yen-Ling Tsai, Wan-Chuan Hung, Ruo-Wei Chen I.-Y. Shu, Kai-Hsiang SZU-YU PAN FENG-JUNG YANG Ting, Te-Tien Jiang, Ju-Ying Peng, Yu-Sen Chuang, Yi-Fang |
關鍵字: | BMI; CKD; Diabetes; Immunosenescence; T cell | 公開日期: | 2020 | 出版社: | BioMed Central Ltd | 卷: | 17 | 期: | 1 | 起(迄)頁: | 31 | 來源出版物: | Immunity and Ageing | 摘要: | Background: Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced renal failure suffer from immunosenescence and premature T cell aging, but whether such changes develop in patients with less severe chronic kidney disease (CKD) is unclear. Method: 523 adult patients with type 2 diabetes were recruited for this study. Demographic data and clinical information were obtained from medical chart review. Immunosenescence, or aging of the immune system was assessed by staining freshly-obtained peripheral blood with immunophenotyping panels and analyzing cells using multicolor flow cytometry. Result: Consistent with previously observed in the general population, both T and monocyte immunosenescence in diabetic patients positively correlate with age. When compared to diabetic patients with preserved renal function (estimated glomerular filtration rate > 60 ml/min), patients with impaired renal function exhibit a significant decrease of total CD3+ and CD4+ T cells, but not CD8+ T cell and monocyte numbers. Immunosenescence was observed in patients with CKD stage 3 and in patients with more severe renal failure, especially of CD8+ T cells. However, immunosenescence was not associated with level of proteinuria level or glucose control. In age, sex and glucose level-adjusted regression models, stage 3 CKD patients exhibited significantly elevated percentages of CD28?, CD127?, and CD57+ cells among CD8+ T cells when compared to patients with preserved renal function. In contrast, no change was detected in monocyte subpopulations as renal function declined. In addition, higher body mass index (BMI) is associated with enhanced immunosenescence irrespective of CKD status. Conclusion: The extent of immunosenescence is not significantly associated with proteinuria or glucose control in type 2 diabetic patients. T cells, especially the CD8+ subsets, exhibit aggravated characteristics of immunosenescence during renal function decline as early as stage 3 CKD. In addition, inflammation increases since stage 3 CKD and higher BMI drives the accumulation of CD8+CD57+ T cells. Our study indicates that therapeutic approaches such as weight loss may be used to prevent the emergence of immunosenescence in diabetes before stage 3 CKD. ? 2020, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092908124&doi=10.1186%2fs12979-020-00200-1&partnerID=40&md5=b8f67d7d5e39cf5323be185f79a291f0 https://scholars.lib.ntu.edu.tw/handle/123456789/579237 |
ISSN: | 1742-4933 | DOI: | 10.1186/s12979-020-00200-1 | SDG/關鍵字: | glucose; adult; Article; body mass; CD3+ T lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; cell aging; controlled study; demography; diabetic nephropathy; disease association; estimated glomerular filtration rate; female; flow cytometry; glucose blood level; human; human cell; immunophenotyping; immunosenescence; kidney failure; kidney function; major clinical study; male; monocyte; non insulin dependent diabetes mellitus; pathogenesis; priority journal; proteinuria |
顯示於: | 醫學系 |
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