https://scholars.lib.ntu.edu.tw/handle/123456789/579273
標題: | Cystatin C as a predictor for outcomes in patients with negligible renal function | 作者: | Ho L.-C. Sung J.-M. Tsai Y.-S. Wang H.-H. Li Y.-C. YI-TING CHEN Chang M.-Y. Hung S.-Y. |
關鍵字: | Cardiovascular risks; Cystatin C; Dialysis; Infection risks; Residual renal function | 公開日期: | 2014 | 出版社: | S. Karger AG | 卷: | 38 | 期: | 2 | 起(迄)頁: | 81-88 | 來源出版物: | Blood Purification | 摘要: | Background: High serum cystatin C (CysC) has been associated with clinical risks independently of the glomerular filtration rate (GFR). This study aims to investigate the predictive power of CysC in patients with a negligible GFR. Methods: Patients on chronic hemodialysis or peritoneal dialysis were enrolled for measurement of CysC levels and were followed up for one year. A daily urine amount <100 ml was considered negligible residual renal function (RRF). Results: CysC results were available in 183 dialysis patients. Of these, 131 patients had a negligible RRF. The multivariate Cox proportional hazards model showed that CysC was an independent predictor of fatal and nonfatal cardiovascular and infection events in all dialysis patients and in dialysis patients with a negligible RRF. Conclusion: CysC maintained its predictive power for adverse outcomes in patients with no meaningful GFR, indicating that the prognostic value of CysC is independent of the GFR. ? 2014 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908159445&doi=10.1159%2f000365837&partnerID=40&md5=ccfd04bbc46da5f5dea842e6eccc1594 https://scholars.lib.ntu.edu.tw/handle/123456789/579273 |
ISSN: | 0253-5068 | DOI: | 10.1159/000365837 | SDG/關鍵字: | albumin; cystatin C; biological marker; CST3 protein, human; cystatin C; adult; albumin blood level; Article; cardiovascular disease; female; follow up; glomerulus filtration rate; hemodialysis; human; infection; kidney function; major clinical study; male; middle aged; peritoneal dialysis; predictive value; priority journal; prognosis; aged; blood; Cardiovascular Diseases; complication; glomerulus filtration rate; kidney; metabolism; Opportunistic Infections; pathophysiology; prognosis; proportional hazards model; Renal Insufficiency, Chronic; renal replacement therapy; treatment outcome; Adult; Aged; Biological Markers; Cardiovascular Diseases; Cystatin C; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Opportunistic Infections; Peritoneal Dialysis; Prognosis; Proportional Hazards Models; Renal Dialysis; Renal Insufficiency, Chronic; Treatment Outcome |
顯示於: | 醫學系 |
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