Peri-radiosurgical administration of bevacizumab improves radiographic response to single and fractionated stereotactic radiosurgery for large brain metastasis
Journal
Journal of neuro-oncology
Journal Volume
153
Journal Issue
3
Date Issued
2021-07
Author(s)
Chen, Yi-Lun
Chen, Hung-Yi
Abstract
Stereotactic radiosurgery (SRS) is a standard of care for brain metastases (BM) patients, yet large BM are at a greater risk for radionecrosis and local progression (LP). Concomitant bevacizumab and radiotherapy has been shown to improve outcomes in primary and metastatic brain tumors. This retrospective study investigated the efficacy and safety of concurrent bevacizumab and SRS for large BM.
Subjects
Bevacizumab; Brain metastases; Radionecrosis; Response; Stereotactic radiosurgery
Other Subjects
bevacizumab; bevacizumab; adult; Article; brain hemorrhage; brain metastasis; brain radiography; disease course; female; human; hypertension; local progression; major clinical study; male; multiple cycle treatment; perioperative period; radiation dose fra
Type
journal article