High-dose tamoxifen reverses drug resistance to cisplatin and etoposide in a patient with advanced large cell carcinoma of lung
Journal
Anticancer Research
Journal Volume
17
Journal Issue
2B
Pages
1341-1344
Date Issued
1997
Author(s)
Abstract
A 64-year-old man was diagnosed as having large cell carcinoma of lung and suffered from recurrent tumors after repeated surgical resection and local irradiation. Systemic chemotherapy with chronic oral etoposide, and then 5 courses of intravenous cisplatin and etoposide (PE) resulted in disease progression with multiple new lung nodules and a severe superior vena cava syndrome. Empirical treatment with a PET regimen, which incorporated high-dose tamoxifen (TAM) 150 mg/m2/day into original PE regimen, was tried. Nearly total tumor necrosis was achieved after 5 courses of PET with remission duration of 4.5 months. The excellent response by simple addition of TAM into a previously inactive PE regimen advocates further investigation.
SDGs
Other Subjects
cisplatin; etoposide; tamoxifen; adult; article; cancer recurrence; case report; disease course; human; intravenous drug administration; large cell carcinoma; lung carcinoma; lung nodule; male; oral drug administration; priority journal; superior cava vein syndrome; tumor necrosis; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Cisplatin; Drug Resistance; Etoposide; Humans; Lung Neoplasms; Male; Middle Aged; Tamoxifen
Type
journal article