https://scholars.lib.ntu.edu.tw/handle/123456789/581541
標題: | Oxytocin signaling acts as a marker for environmental stressors in zebrafish | 作者: | Chuang H.-J Chang C.-Y Ho H.-P Chou M.-Y. MING-YI CHOU |
關鍵字: | oxytocic agent; oxytocin; animal; animal behavior; brain; drug effect; environment; nerve cell; pathology; physiological stress; transgenic animal; zebra fish; Animals; Animals, Genetically Modified; Behavior, Animal; Brain; Environment; Neurons; Oxytocics; Oxytocin; Stress, Physiological; Zebrafish | 公開日期: | 2021 | 卷: | 22 | 期: | 14 | 起(迄)頁: | 7459 | 來源出版物: | International Journal of Molecular Sciences | 摘要: | The oxytocin system plays a role in stress responses and behavior modulation. However, the effects of oxytocin signaling on stress adaptation remain unclear. Here, we demonstrated the roles of oxytocin signaling as a biomarker under stress conditions in the peripheral tissues (the gills) and central nervous system (the brain). All the environmental stressors downregulated the expression of oxytocin receptors in the gills, and the alteration of the expression of oxytocin receptors was also found in the brain after the acidic (AC) and high-ammonia (HA) treatments. The number of oxytocin neurons was increased after double-deionized (DI) treatment. By transgenic line, Tg(oxtl:EGFP), we also investigated the projections of oxytocin neurons and found oxytocin axon innervations in various nuclei that might regulate the anxiety levels and aggressiveness of adult zebrafish under different environmental stresses. The oxytocin system integrates physiological responses and behavioral outcomes to ensure environmental adaptation in adult zebrafish. Our study provides insight into oxytocin signaling as a stress indicator upon environmental stressors. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109609958&doi=10.3390%2fijms22147459&partnerID=40&md5=e6c84d9d1741941facc13f27b7efe406 https://scholars.lib.ntu.edu.tw/handle/123456789/581541 |
DOI: | 10.3390/ijms22147459 |
顯示於: | 生命科學系 |
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