https://scholars.lib.ntu.edu.tw/handle/123456789/581622
標題: | Eyelid sebaceous carcinoma: Validation of the 8th edition of the American Joint Committee on cancer T staging system and the prognostic factors for local recurrence, nodal metastasis, and survival | 作者: | Hsia Y. Yeh C.-Y. YI-HSUAN WEI Chen L.-W. SHU-LANG LIAO |
公開日期: | 2019 | 出版社: | Nature Publishing Group | 卷: | 33 | 期: | 6 | 起(迄)頁: | 887-895 | 來源出版物: | Eye (Basingstoke) | 摘要: | Purpose: To investigate the clinicopathological features and prognostic factors for eyelid sebaceous gland carcinoma (SGC) in an ethnic Chinese population and to validate the performance of the T category of the 8th edition AJCC staging systems, with the aim of providing information for refinements. Methods: Sixty-three patients with pathological diagnosis of SGC were enroled retrospectively. The clinicopathological features, treatments, and outcomes were collected. Prognostic factors associated with the outcome of local recurrence, regional lymph node metastasis, and tumour-related death were analysed. The performance analysis was performed by comparing the predictive value for survival and the monotonicity of gradients between the 7th and 8th staging systems. Results: The distribution of T1:T2:T3:T4 tumours according to the 7th and 8th edition was 6:40:16:1 and 23:26:5:9, respectively. Positive surgical margin was a poor prognostic factor. Local recurrence was associated with more aggressive histopathological features and surrounding structure invasions. Regional lymph node metastasis was associated with larger tumours. The T category of 8th edition showed better predictability for local recurrence and regional lymph node metastasis, while the T category of 7th edition had better monotonicity of gradients. Tumours classified as T2c or worse had higher risk of regional lymph node metastasis, while tumours T3b or worse in the 8th edition had more tumour-related death. Conclusions: Patients with higher T category are at risk of regional lymph node metastasis and tumour-related death. Further refinement of the T category of AJCC staging system can focus on the predictability for local recurrence and the monotonicity of gradients. ? 2019, ? 2019, The Royal College of Ophthalmologists. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066784038&doi=10.1038%2fs41433-019-0454-7&partnerID=40&md5=700fb68dd1ac18e94c1f3b4f177fcdaa https://scholars.lib.ntu.edu.tw/handle/123456789/581622 |
ISSN: | 0950-222X | DOI: | 10.1038/s41433-019-0454-7 | SDG/關鍵字: | adult; aged; Article; brain metastasis; cancer mortality; cancer prognosis; cancer radiotherapy; cancer staging; cancer survival; Chinese; eyelid carcinoma; eyelid reconstruction; female; histopathology; human; human tissue; liver metastasis; lung metastasis; lymph node metastasis; major clinical study; male; perineural invasion; predictive value; recurrent disease; retrospective study; sebaceous carcinoma; surgical margin; Taiwan; very elderly; adenocarcinoma; biopsy; cause of death; classification; epidemiology; eyelid; eyelid tumor; follow up; lymph node; lymph node metastasis; middle aged; mortality; pathology; prognosis; sebaceous gland tumor; survival rate; Adenocarcinoma, Sebaceous; Adult; Aged; Aged, 80 and over; Biopsy; Cause of Death; Eyelid Neoplasms; Eyelids; Female; Follow-Up Studies; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Prognosis; Retrospective Studies; Sebaceous Gland Neoplasms; Survival Rate; Taiwan |
顯示於: | 醫學系 |
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