https://scholars.lib.ntu.edu.tw/handle/123456789/581922
標題: | New perspectives of biomarkers for the management of chronic hepatitis B | 作者: | Lin C.-L. JIA-HORNG KAO |
關鍵字: | Chronic hepatitis B; HBcrAg; HBsAg; HBV DNA; Total anti-HBc | 公開日期: | 2016 | 出版社: | Korean Association for the Study of the Liver | 卷: | 22 | 期: | 4 | 起(迄)頁: | 423-431 | 來源出版物: | Clinical and Molecular Hepatology | 摘要: | With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC. Hepatitis B core-related antigen (HBcrAg) induces host immune responses, and the reduction of the HbcrAg level as well as the increment of total anti-HBc level are significantly associated with favorable outcomes. HBV genotypes (genotype C/D) and mutants (basal core promoter and deletion mutation in pre-S genes) are well known viral genetic markers to predict disease progression. For host factors, serum inflammatory biomarkers have been developed to evaluate the HBV-associated hepatic necroinflammation and fibrosis. Host single nucleotide polymorphism on sodium taurocholate cotransporting polypeptide (NTCP, an HBV entry receptor) may be associated with a decreased risk for cirrhosis and HCC. In conclusion, patients with chronic hepatitis B should be evaluated with relevant viral and host markers to identify those who are at a higher risk of liver disease progression and then receive timely antiviral therapy. ? 2016 by The Korean Association for the Study of the Liver. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014851007&doi=10.3350%2fcmh.2016.0069&partnerID=40&md5=7a86a6e65436bd893b4921a74be578d5 https://scholars.lib.ntu.edu.tw/handle/123456789/581922 |
ISSN: | 2287-2728 | DOI: | 10.3350/cmh.2016.0069 | SDG/關鍵字: | alanine aminotransferase; biological marker; hepatitis B surface antigen; biological marker; cotransporter; hepatitis B surface antigen; hepatitis B(e) antigen; organic anion transporter; sodium-bile acid cotransporter; virus DNA; antiviral therapy; chronic hepatitis B; disease course; gene mutation; human; immune response; immunological tolerance; inflammation; liver cirrhosis; nonhuman; Review; single nucleotide polymorphism; tumor microenvironment; virus load; blood; complication; genetics; Hepatitis B virus; Hepatitis B, Chronic; liver cirrhosis; risk factor; Biomarkers; DNA, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Organic Anion Transporters, Sodium-Dependent; Polymorphism, Single Nucleotide; Risk Factors; Symporters |
顯示於: | 臨床醫學研究所 |
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