|Title:||Adipocytokines and liver fibrosis stages in patients with chronic hepatitis B virus infection||Authors:||Hsu C.-S.
|Keywords:||Adipocytokine; Chronic hepatitis B; HBsAg; HBV DNA; Hepatitis B virus; Liver fibrosis||Issue Date:||2015||Publisher:||Springer India||Journal Volume:||9||Journal Issue:||2||Start page/Pages:||231-242||Source:||Hepatology International||Abstract:||
Background: Adipocytokines play an important role in lipid metabolism and liver disease progression. However, the interactions between hepatitis B virus (HBV) infection and adipocytokines remain largely unknown. Aims: To investigate the association of HBV infection with adipocytokines in HBV-infected and noninfected subjects. In addition, the impact of adipocytokines on serum HBV DNA, HBsAg levels and liver fibrosis stage was also examined. Methods: A case-control analysis of patients with and without chronic HBV infection was performed. The HBV group consisted of 187 patients with chronic HBV infection, and the control group consisted of 184 age-, gender- and body mass index-matched subjects without HBV infection. Fasting blood glucose, lipid profiles, adiponectin, leptin and visfatin levels were compared between the two groups. APRI and FIB-4 were calculated to estimate the severity of liver fibrosis. Results: Most of the enrolled subjects had lower ALT levels [228 (57.7?%) ALT?
|ISSN:||1936-0533||DOI:||10.1007/s12072-015-9616-2||SDG/Keyword:||adiponectin; alanine aminotransferase; aspartate aminotransferase; hepatitis B surface antigen; hepatitis B(e) antigen; leptin; nicotinamide phosphoribosyltransferase; virus DNA; adult; age; blood; case control study; chronic hepatitis B; cohort analysis; female; human; liver cirrhosis; male; middle aged; pathology; severity of illness index; sex difference; thrombocyte count; virology; Adiponectin; Adult; Age Factors; Alanine Transaminase; Aspartate Aminotransferases; Case-Control Studies; Cohort Studies; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Leptin; Liver Cirrhosis; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Platelet Count; Severity of Illness Index; Sex Factors
|Appears in Collections:||臨床醫學研究所|
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