https://scholars.lib.ntu.edu.tw/handle/123456789/582002
標題: | Hepatitis B viral factors and treatment responses in chronic hepatitis B | 作者: | Lin C.-L. JIA-HORNG KAO |
關鍵字: | Antiviral therapy; Chronic hepatitis B; Hepatitis B virus DNA; Nucleos(t)ide analogs; Pegylated interferon; Quantitative HBsAg | 公開日期: | 2013 | 卷: | 112 | 期: | 6 | 起(迄)頁: | 302-311 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Baseline and on-treatment hepatitis B viral factors are reported to affect treatment responses. A lower baseline hepatitis B virus (HBV) DNA level is a strong predictor of the response to antiviral therapy. HBV genotype A/B patients have better responses to interferon-based therapy than those with genotypes C/D. Regarding the association of HBV mutants with responses to antiviral therapy, current evidence is limited. On-treatment viral suppression is the most important predictor of response to nucleoside analogs. On-treatment hepatitis B surface antigen decline is significantly associated with response to pegylated interferon. In the future, individualized therapy should be based on treatment efficacy, adverse effects, baseline and on-treatment predictors of antiviral therapy. ? 2012, Elsevier Taiwan LLC & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879158955&doi=10.1016%2fj.jfma.2013.02.001&partnerID=40&md5=f84ff6e611c965cc84945f22ada00ebc https://scholars.lib.ntu.edu.tw/handle/123456789/582002 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2013.02.001 | SDG/關鍵字: | adefovir; adefovir dipivoxil; alanine aminotransferase; alpha interferon; creatinine; entecavir; hepatitis B surface antigen; lamivudine; peginterferon alpha; peginterferon alpha2a; peginterferon alpha2b; telbivudine; tenofovir disoproxil; virus DNA; antiviral resistance; antiviral therapy; clinical effectiveness; competitive inhibition; creatinine blood level; disease association; disease exacerbation; drug efficacy; drug half life; genotype; hepatitis B; Hepatitis B virus; human; liver cirrhosis; monotherapy; mutational analysis; nephrotoxicity; predictive value; review; risk factor; seroconversion; side effect; treatment duration; treatment response; viremia; virus strain; Antiviral Agents; DNA, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Polyethylene Glycols; Recombinant Proteins |
顯示於: | 臨床醫學研究所 |
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