https://scholars.lib.ntu.edu.tw/handle/123456789/582149
標題: | Association of chronic hepatitis B virus infection with insulin resistance and hepatic steatosis | 作者: | Wang C.-C. Hsu C.-S. CHUN-JEN LIU JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2008 | 出版社: | Blackwell Publishing | 卷: | 23 | 期: | 5 | 起(迄)頁: | 779-782 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aim: Chronic viral infections such as human immunodeficiency virus and hepatitis C virus (HCV) may decrease tissue response to insulin, thereby causing insulin resistance. In addition, insulin resistance is associated with hepatic steatosis. However, whether these phenomena hold true for chronic hepatitis B virus (HBV) infection remains largely unknown. The present study therefore aimed to investigate the association of chronic HBV infection with insulin resistance and hepatic steatosis. Methods: A total of 507 subjects (243 men and 264 women; mean age 46.56 years) less than 60 years-old attending a health examination center were enrolled in the study. All the subjects were negative for antibodies against HCV and consumed less than 140 g alcohol/week. Demographic, anthropometric, clinical, and laboratory data were obtained from each subject. Insulin resistance index was determined using homeostasis model assessment (HOMA-IR). Hepatic steatosis was identified by ultrasound examination. Results: Of the 507 subjects, 50 (9.9%) were positive for hepatitis B surface antigen (HBsAg) and designated HBV carriers. All variables were comparable between HBV carriers and non-HBV carriers, except that HBV carriers had significantly higher serum alanine aminotransferase and aspartate aminotransferase levels (P < 0.05). By multivariate linear regression, HBV carriers were not associated with insulin resistance. In addition, multivariate regression analyses showed that HBV carriers were not associated with the presence of ultrasonographic fatty liver. Conclusions: Chronic HBV infection seems not to be associated with insulin resistance or hepatic steatosis in HBV carriers. ? 2007 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-42049119699&doi=10.1111%2fj.1440-1746.2007.05216.x&partnerID=40&md5=198795fd7ad810eb4e204b5d7a34ca9b https://scholars.lib.ntu.edu.tw/handle/123456789/582149 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2007.05216.x | SDG/關鍵字: | alkaline phosphatase; cholesterol; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; adult; anthropometry; article; chronic hepatitis; demography; disease association; fatty liver; female; hepatitis B; heterozygote; histopathology; human; Human immunodeficiency virus; Human immunodeficiency virus infection; insulin resistance; major clinical study; male; priority journal |
顯示於: | 臨床醫學研究所 |
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