Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: A comparison with chronic carriers
Journal
Liver International
Journal Volume
27
Journal Issue
10
Pages
1356-1363
Date Issued
2007
Author(s)
Abstract
Background: Chronic hepatitis B virus (HBV) infection is associated with hepatocellular carcinoma (HCC), and specific viral factors have been identified that may increase the risk for HCC development. However, the differences in these viral factors in chronic carriers who seldom develop HCC compared with HCC patients have not been adequately evaluated. Methods: From 1989 to 2005, 101 hepatitis B surface antigen-positive patients presented to our clinic with HCC. Baseline basal core promoter (BCP) T1762/A1764 mutants, precore (PC) A1896 mutants, HBV genotypes and HBV DNA in HCC patients were compared with 67 chronic carriers who had been followed for a mean of 112.1 ± 77.7 standard deviation months. Results: At baseline, HCC patients had lower levels of serum albumin, but higher values of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, bilirubin and α-foetoprotein than those of chronic carriers (P < 0.001 for all comparisons). The presence of genotype C, higher frequencies of PC A1896 mutants, BCP T1762/A1764 mutants and higher circulating levels of HBV DNA were more frequently detected in HCC patients than that in chronic carriers (P < 0.001 for all observations). Logistic regression analysis revealed that BCP T1762/A1764 mutants [odds ratio (OR) 11.14, 95% confidence interval (CI) 3.05-40.72; P <0.001] and PC A1896 mutants (OR 3.75, 95% CI 1.14-12.34; P < 0.05) were significantly associated with HCC development. Conclusion: Our results indicate that the presence of BCP and PC mutations significantly increases the risk for HCC in chronic hepatitis B patients. These mutations were less often detected in chronic carriers who seldom develop HCC. ? 2007 Blackwell Munksgaard.
Subjects
Basal core promoter mutants; Chronic carriers; HBV DNA; HBV genotypes; Hepatocellular carcinoma; Precore mutants
SDGs
Other Subjects
alanine; alanine aminotransferase; albumin; alkaline phosphatase; alpha fetoprotein; aspartate aminotransferase; bilirubin; hepatitis B surface antigen; threonine; virus DNA; adult; aged; alanine aminotransferase blood level; albumin blood level; alkaline phosphatase blood level; article; aspartate aminotransferase blood level; bilirubin blood level; cancer risk; confidence interval; controlled study; female; gene mutation; genotype; hepatitis B; Hepatitis B virus; human; liver carcinogenesis; liver cell carcinoma; logistic regression analysis; major clinical study; male; promoter region; protein blood level; risk factor; statistical significance; virus carcinogenesis; virus carrier; virus mutant; Adult; Aged; Carcinoma, Hepatocellular; DNA, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Logistic Models; Male; Middle Aged; Point Mutation; Prevalence; Promoter Regions (Genetics); Risk Factors
Type
journal article