https://scholars.lib.ntu.edu.tw/handle/123456789/582182
標題: | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma | 作者: | Tong M.J. Blatt L.M. JIA-HORNG KAO Cheng J.T. Corey W.G. |
關鍵字: | Basal core promoter mutants; Hepatitis B e antigen; Hepatitis B viral DNA; Hepatitis B viral genotypes; Hepatocellular carcinoma; Liver failure; Precore mutants | 公開日期: | 2006 | 出版社: | Baishideng Publishing Group Co | 卷: | 12 | 期: | 41 | 起(迄)頁: | 6620-6626 | 來源出版物: | World Journal of Gastroenterology | 摘要: | Aim: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma. Methods: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. Results: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1-16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.021 and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to henatocellular carcinoma. Conclusion: Our results show that high levels of baseline serum HBV DNA are associated with non-hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. ? 2006 The WJG Press. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33751299464&doi=10.3748%2fwjg.v12.i41.6620&partnerID=40&md5=053cfdf1da97c7c70b1bf4702615842b https://scholars.lib.ntu.edu.tw/handle/123456789/582182 |
ISSN: | 1007-9327 | DOI: | 10.3748/wjg.v12.i41.6620 | SDG/關鍵字: | alpha fetoprotein; hepatitis B(e) antibody; hepatitis B(e) antigen; virus DNA; adult; age; article; Asian; computer assisted tomography; controlled study; death; disease association; disease course; echography; esophagus varices bleeding; female; follow up; gene mutation; genotype; hepatitis B; Hepatitis B virus; human; liver biopsy; liver cell carcinoma; liver failure; logistic regression analysis; major clinical study; male; multivariate analysis; nuclear magnetic resonance imaging; nucleotide sequence; prediction; promoter region; race difference; real time polymerase chain reaction; sepsis; sex ratio; univariate analysis; virus mutant |
顯示於: | 臨床醫學研究所 |
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