https://scholars.lib.ntu.edu.tw/handle/123456789/582272
標題: | Probable reinfection with hepatitis C virus in a chronic hepatitis C patient with a sustained response to combination therapy | 作者: | JIA-HORNG KAO Lai M.-Y. PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 2001 | 出版社: | Elsevier (Singapore) Pte Ltd | 卷: | 100 | 期: | 12 | 起(迄)頁: | 824-828 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Abstract: Superinfection with hepatitis C virus (HCV) in already chronically infected subjects has been documented. Whether a complete response to antiviral therapy is associated with protective immunity against reinfection with HCV remains unknown. We describe a patient who had a sustained biochemical and virologic response with loss of intrahepatic HCV RNA after a course of combination therapy using interferon plus ribavirin. Histopathologically, the chronic hepatitis was in remission on follow-up biopsy 6 months post-therapy. Unfortunately, 34 weeks post-therapy, a flare of hepatitis with reappearance of hepatitis C viremia was noted 2 months after he received injections from a non-licensed medical provider. Analysis of the core gene sequences showed a 95% homology between the HCV strains isolated before antiviral treatment and during the hepatitis flare. The data indicated that the hepatitis flare after a period of sustained response to combination therapy in this patient could have been caused by reinfection with homotypic HCV. Our observation indicates the lack of protective immunity against reinfection with HCV in patients with chronic hepatitis C, even after successful clearance of the virus. Therefore, reinforcing the education of these subjects to avoid HCV reinfection should be stressed. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983722798&partnerID=40&md5=4b47b1edcb9053566fb10d0b2660f608 https://scholars.lib.ntu.edu.tw/handle/123456789/582272 |
ISSN: | 0929-6646 | SDG/關鍵字: | alpha2a interferon; ribavirin; virus RNA; adult; article; case report; chronic disease; clearance; disease exacerbation; drug response; follow up; gene sequence; general practitioner; genetic analysis; hepatitis C; histopathology; human; liver biopsy; male; patient education; reinfection; remission; sequence homology; superinfection; viremia; virus immunity; virus isolation; virus strain |
顯示於: | 臨床醫學研究所 |
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