https://scholars.lib.ntu.edu.tw/handle/123456789/582273
標題: | Post-partum acute exacerbation of chronic hepatitis in a hepatitis C-carrier mother | 作者: | Chen J.-D. Chung J.-L. JIA-HORNG KAO DING-SHINN CHEN |
關鍵字: | Acute exacerbation; Chronic hepatitis; Hepatitis C virus; Post-partum; Pregnant woman | 公開日期: | 2001 | 卷: | 16 | 期: | 6 | 起(迄)頁: | 705-708 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Hepatitis C virus infection is a global health problem; however, the interaction between pregnancy and chronic hepatitis C remains controversial. A Taiwanese woman with chronic hepatitis C had an uncomplicated pregnancy and gave birth to a female baby through spontaneous vaginal delivery. The serum levels of alanine aminotransferase and hepatitis C virus (HCV) RNA were measured before pregnancy, in the first and third trimesters, 1 and 3 months after delivery, respectively. During her pregnancy, the serum aminotransferase levels became normalized, while the serum HCV-RNA levels declined significantly and consecutively with the lowest viral load in the third trimester. One month after delivery, she had an abrupt elevation of serum HCV-RNA level, paralleling a hepatitis flare with serum aminotransferase level more than 20-fold the upper normal limit. The serum HCV-RNA levels declined thereafter, and serum aminotransferase levels became normalized 3 months postdelivery. She was infected with HCV genotype 1a throughout the entire follow-up period, and other causes of hepatitis flare were excluded. In conclusion, post-partum acute exacerbation of chronic hepatitis may occur in HCV-carrier mothers, and an abrupt elevation of serum HCV-RNA level may be associated with the acute exacerbation. ? 2001 Blackwell Science Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035720743&doi=10.1046%2fj.1440-1746.2001.02502.x&partnerID=40&md5=e61e17ce9495a307ce30661cfbdbd044 https://scholars.lib.ntu.edu.tw/handle/123456789/582273 |
ISSN: | 0815-9319 | DOI: | 10.1046/j.1440-1746.2001.02502.x | SDG/關鍵字: | alanine aminotransferase; virus RNA; adult; article; blood level; case report; clinical feature; disease association; disease course; disease exacerbation; female; first trimester pregnancy; genotype; hepatitis C; Hepatitis C virus; human; mother; pregnancy; priority journal; puerperium; Taiwan; third trimester pregnancy; vaginal delivery; virus carrier; virus load |
顯示於: | 臨床醫學研究所 |
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