https://scholars.lib.ntu.edu.tw/handle/123456789/582294
標題: | GB virus-C/hepatitis G virus infection in Taiwan: A virus that fails to cause a disease? | 作者: | JIA-HORNG KAO DING-SHINN CHEN |
關鍵字: | Flaviviridae; GB virus-C; Hepatitis B virus; Hepatitis G virus; RNA virus | 公開日期: | 1999 | 出版社: | BioMed Central Ltd. | 卷: | 6 | 期: | 4 | 起(迄)頁: | 220-225 | 來源出版物: | Journal of Biomedical Science | 摘要: | Recently, an RNA virus designated GB virus-C or hepatitis G virus (GBV- C/HGV) was identified; however, its clinical significance remains uncertain. This discovery prompted us to investigate the virological, epidemiological and clinical implications of GBV-C/HGV infection in Taiwan where chronic liver diseases and liver cancer are endemic. Our results showed that genetic heterogeneity of GBV-C/HGV isolates exists, and primers from the highly conserved 5' untranslated region of viral genome can efficiently detect GBV- C/HGV RNA. Epidemiological surveys showed that GBV-C/HGV infection is common in high-risk groups in Taiwan, and its coinfection does not aggravate the course of chronic hepatitis B or C. A prospective study of transfusion- transmitted GBV-C/HGV infection also showed GBV-C/HGV does not cause classic hepatitis in most patients. In addition, GBV-C/HGV plays a minimal role in causing fulminant hepatitis. Like hepatitis C virus, sexual transmission of GBV-C/HGV exists. The risk increases with prolonged duration of exposure. In addition, high-titered maternal viremia and mode of delivery are associated with the mother-to-infant trans- mission of GBV-C/HGV. Interestingly, we found that GBV-C/HGV exerts no suppression on levels of chronic hepatitis B or hepatitis C viremia, and GBV-C/HGV responds to interferon; however, ribavirin plus interferon does not induce a higher sustained response. As to the replication sites of GBV-C/HGV, our preliminary results showed liver and peripheral blood mononuclear cells are not the major sites for GBV-C/HGV replication, and thus GBV-C/HGV is not a primary hepatotropic virus. In conclusion, transfusion and exchange of body fluids indeed can transmit GBV- C/HGV; however, current lines of evidence suggest that GBV-C/HGV fails to cause a disease. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032787953&doi=10.1007%2fBF02253563&partnerID=40&md5=b7fdc80728d1d5f5ceffe5d44f42e7a8 https://scholars.lib.ntu.edu.tw/handle/123456789/582294 |
ISSN: | 1021-7770 | DOI: | 10.1007/BF02253563 | SDG/關鍵字: | Flavivirus; genetic heterogeneity; hepatitis; Hepatitis G virus; nonhuman; priority journal; review; RNA virus; sexual transmission; Taiwan; vertical transmission; virus characterization; virus virulence; Flaviviridae; Flavivirus; GB virus C/Hepatitis G virus; Hepatitis B virus; Hepatitis C virus; RNA viruses |
顯示於: | 臨床醫學研究所 |
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