https://scholars.lib.ntu.edu.tw/handle/123456789/582410| Title: | Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis | Authors: | Bieber, Thomas Simpson, Eric L Silverberg, Jonathan I Thaçi, Diamant Paul, Carle Pink, Andrew E Kataoka, Yoko CHIA-YU CHU DiBonaventura, Marco Rojo, Ricardo Antinew, Jeremias Ionita, Ileana Sinclair, Rodney Forman, Seth Zdybski, Jacek Biswas, Pinaki Malhotra, Bimal Zhang, Fan Valdez, Hernan |
Issue Date: | 2021 | Journal Volume: | 384 | Journal Issue: | 12 | Source: | The New England journal of medicine | Abstract: | The oral Janus kinase 1 (JAK1) inhibitor abrocitinib, which reduces interleukin-4 and interleukin-13 signaling, is being investigated for the treatment of atopic dermatitis. Data from trials comparing JAK1 inhibitors with monoclonal antibodies, such as dupilumab, that block interleukin-4 receptors are limited. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/582410 | ISSN: | 00284793 | DOI: | 10.1056/NEJMoa2019380 | SDG/Keyword: | [SDGs]SDG3 abrocitinib; dupilumab; placebo; abrocitinib; dupilumab; immunoglobulin A; interleukin 4 receptor alpha; Janus kinase 1; monoclonal antibody; placebo; protein kinase inhibitor; pyrimidine derivative; sulfonamide; adult; Article; atopic dermatitis; comparative effectiveness; controlled study; dose response; double blind procedure; drug dose comparison; drug safety; female; human; loading drug dose; major clinical study; male; nausea; phase 3 clinical trial; priority journal; prospective study; randomized controlled trial; skin pruritus; atopic dermatitis; blood; clinical trial; comparative study; multicenter study; oral drug administration; pruritus; severity of illness index; subcutaneous drug administration; Administration, Oral; Adult; Antibodies, Monoclonal, Humanized; Dermatitis, Atopic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Immunoglobulin A; Injections, Subcutaneous; Interleukin-4 Receptor alpha Subunit; Janus Kinase 1; Male; Placebos; Protein Kinase Inhibitors; Pruritus; Pyrimidines; Severity of Illness Index; Sulfonamides |
| Appears in Collections: | 醫學系 |
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