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  4. 3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
 
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3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

Journal
Scientific Reports
Journal Volume
7
Journal Issue
1
Pages
4466
Date Issued
2017
Author(s)
KUO-TAI HUA  
Liu Y.-F.
CHIA-LANG HSU  
TSU-YAO CHENG  
CHING-YAO YANG  
Chang J.-S.
Lee W.-J.
Hsiao M.
Juan H.-F.  
Chien M.-H.
Yang S.-F.
DOI
10.1038/s41598-017-04732-3
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021675317&doi=10.1038%2fs41598-017-04732-3&partnerID=40&md5=75983193cfe7c26cd511801c2a068152
https://scholars.lib.ntu.edu.tw/handle/123456789/582952
Abstract
Carbonic anhydrase IX (CA9) expression level has been considered as a poor prognostic factor in hepatocellular carcinoma (HCC) patients. However, the judging criteria of CA9 level is hard to define for potential clinical applications. Unlike CA9 expression level, CA9 polymorphism is poorly documented in HCC. Here, we found that people carry A allele at CA9 rs1048638, a 3′UTR SNP, has higher risk of HCC. rs1048638-CA correlates with advanced stages, larger tumor sizes, more vascular invasion, and shorter survival of HCC patients. A allele at CA9 rs1048638 impairs miR-34a, a tumor suppressor miRNA in HCC, binding to CA9 3′UTR and desensitizes CA9 mRNA to miR-34a-dependent RNA degradation. CA9 expression levels were also correlated with miR-34a levels and rs1048638 genotypes in HCC patients. rs1048638 influences HCC risk and progression through effects on miR-34a-targeted CA9 expression in HCC. In conclusion, genetic variations of the CA9 3′UTR play important roles in regulating CA9 expression and cancer progression, which is a novel determinant and target for HCC metastasis and prognosis. ? 2017 The Author(s).
SDGs

[SDGs]SDG3

Other Subjects
carbonate dehydratase IX; microRNA; MIRN34 microRNA, human; tumor marker; 3' untranslated region; allele; cancer grading; cancer staging; cell motion; cell proliferation; gene expression regulation; genetic predisposition; genetics; genotype; human; Kaplan Meier method; liver cell carcinoma; liver tumor; metastasis; mortality; odds ratio; pathology; prognosis; RNA interference; single nucleotide polymorphism; 3' Untranslated Regions; Alleles; Biomarkers, Tumor; Carbonic Anhydrase IX; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Humans; Kaplan-Meier Estimate; Liver Neoplasms; MicroRNAs; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Odds Ratio; Polymorphism, Single Nucleotide; Prognosis; RNA Interference
Publisher
Nature Publishing Group
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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