https://scholars.lib.ntu.edu.tw/handle/123456789/583091
標題: | Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease | 作者: | Goletti D. MENG-RUI LEE JANN-YUAN WANG Walter N. Ottenhoff T.H.M. |
公開日期: | 2018 | 出版社: | Blackwell Publishing | 卷: | 23 | 期: | 5 | 起(迄)頁: | 455-466 | 來源出版物: | Respirology | 摘要: | Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB-BM) would constitute extremely useful tools to measure infection status and predict outcome of infection, vaccination or therapy. There are several types of TB-BM: Correlate of Infection; Correlate of TB Disease; Correlate of Increased Risk of Developing Active TB Disease; Correlate of the Curative Response to Therapy; and Correlate of Protection (CoP). Most TB-BM currently studied are host-derived BM, and consist of transcriptomic, proteomic, metabolomic, cellular markers or marker combinations (‘signatures’). In particular, vaccine-inducible CoP are expected to be transformative in developing new TB vaccines as they will de-risk vaccine research and development (R&D) as well as human testing at an early stage. In addition, CoP could also help minimizing the need for preclinical studies in experimental animals. Of key importance is that TB-BM are tested and validated in different well-characterized human TB cohorts, preferably with complementary profiles and geographically diverse populations: genetic and environmental factors such as (viral) coinfections, exposure to non-tuberculous mycobacteria, nutritional status, metabolic status, age (infants vs children vs adolescents vs adults) and other factors impact host immune set points and host responses across different populations. In this study, we review the most recent advances in research into TB-BM for the diagnosis of active TB, risk of TB development and treatment-induced TB cure. ? 2018 Asian Pacific Society of Respirology |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042064378&doi=10.1111%2fresp.13272&partnerID=40&md5=61e21f4d0f6f797a4ad72ba5950bb234 https://scholars.lib.ntu.edu.tw/handle/123456789/583091 |
ISSN: | 1323-7799 | DOI: | 10.1111/resp.13272 | SDG/關鍵字: | bacterial DNA; biological marker; fibrinogen; gamma interferon; gamma interferon inducible protein 10; HLA DR antigen; interleukin 10; interleukin 1beta; interleukin 23; Ki 67 antigen; scleroprotein; scleroprotein 1; tumor necrosis factor; unclassified drug; volatile organic compound; bacterial antigen; bacterial DNA; bacterium antibody; BCG vaccine; biological marker; proteome; transcriptome; bacterial load; blood analysis; CD4+ T lymphocyte; cellular immunity; correlational study; disease course; genome analysis; host pathogen interaction; human; interferon gamma release assay; Mycobacterium tuberculosis; pathogenesis; polymerase chain reaction; positron emission tomography-computed tomography; prediction; priority journal; proteomics; quantitative analysis; Review; RNA sequence; saliva analysis; sensitivity and specificity; serology; sputum analysis; T lymphocyte; T lymphocyte activation; transcriptomics; treatment response; tuberculin test; tuberculosis; urinalysis; blood; immunology; latent tuberculosis; metabolome; risk assessment; tuberculosis; urine; Antibodies, Bacterial; Antigens, Bacterial; Biomarkers; DNA, Bacterial; Humans; Latent Tuberculosis; Metabolome; Mycobacterium tuberculosis; Proteome; Risk Assessment; Transcriptome; Tuberculosis; Tuberculosis Vaccines |
顯示於: | 醫學系 |
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