https://scholars.lib.ntu.edu.tw/handle/123456789/583111
標題: | Capsular serotypes and antimicrobial susceptibilities of Streptococcus pneumoniae causing invasive pneumococcal disease from 2009-2012 with an emphasis on serotype 19A in bacteraemic pneumonia and empyema and β-lactam resistance | 作者: | MENG-RUI LEE Chen C.-M. Chuang T.-Y. YU-TSUNG HUANG PO-REN HSUEH |
公開日期: | 2013 | 卷: | 42 | 期: | 5 | 起(迄)頁: | 395-402 | 來源出版物: | International Journal of Antimicrobial Agents | 摘要: | Capsular serotypes and antimicrobial susceptibilities of Streptococcus pneumoniae isolates that cause invasive pneumococcal disease (IPD) were studied and the role of serotype 19A in the development of bacteraemic pneumonia and empyema was investigated. Subjects comprised 98 patients (56 adults and 42 children) who were treated for IPD at a university-affiliated tertiary referral centre in Taiwan during 2009-2012. Serotypes of the isolates were identified using the latex agglutination method. In vitro susceptibilities of the isolates to 13 antimicrobial agents were determined using the broth microdilution method and were interpreted as recommended by the Clinical and Laboratory Standards Institute. During the study period, bacteraemic pneumonia was the most common type of infection (43/98; 43.9%), followed by primary bacteraemia (30/98; 30.6%). Serotype 19A was the most common serotype (23/98; 23.5%) in all patients. Fourteen (70.0%) of 20 children (47.6% of all children) with serotype 19A infection had pneumonia with empyema, whilst eight patients had concomitant bacteraemia. 7-valent pneumococcal conjugated vaccine (PCV-7), PCV-10, PCV-13 and 23-valent pneumococcal polysaccharide vaccine (PPV-23) had coverage rates of 37.8%, 38.8%, 79.6% and 77.6%, respectively. A substantial increase in the proportion of serotype 15A (6.1%) and 6A (8.2%) was found. In addition, there was a significant reduction in rates of susceptibility of serotype 19A isolates to penicillin, cefotaxime and ceftriaxone but not to azithromycin or any quinolone tested compared with those of non-19A isolates. The prevalence of serotypes 19A, 15A and 6A in patients with IPD increased markedly during the period, especially in children with bacteraemic pneumonia and empyema. ? 2013 Elsevier B.V. and the International Society of Chemotherapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885432518&doi=10.1016%2fj.ijantimicag.2013.07.017&partnerID=40&md5=e5e96b90e5b1b890fdc9b92aba0fd4f6 https://scholars.lib.ntu.edu.tw/handle/123456789/583111 |
ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2013.07.017 | SDG/關鍵字: | azithromycin; beta lactam antibiotic; cefotaxime; ceftazidime; ceftobiprole; ceftriaxone; daptomycin; gemifloxacin; levofloxacin; linezolid; moxifloxacin; nemonoxacin; penicillin derivative; penicillin V; Pneumococcus vaccine; quinoline derived antiinfective agent; sultamicillin; tigecycline; vancomycin; adolescent; adult; aged; antibiotic resistance; antibiotic sensitivity; article; bacteremia; bacterial capsule; bacterium isolation; child; controlled study; empyema; female; human; in vitro study; infant; major clinical study; male; mixed infection; nonhuman; pneumococcal infection; preschool child; priority journal; school child; serotype; strain identification; Streptococcus pneumonia; Streptococcus pneumoniae; Taiwan; Empyema; Pneumonia; Serotypes 19A, 15A, 6A; Streptococcus pneumoniae; Taiwan; Adolescent; Adult; Aged; Aged, 80 and over; Bacteremia; beta-Lactam Resistance; Child; Child, Preschool; Empyema; Female; Humans; Infant; Infant, Newborn; Male; Microbial Sensitivity Tests; Middle Aged; Pneumonia, Pneumococcal; Prevalence; Serotyping; Streptococcus pneumoniae; Taiwan; Tertiary Care Centers; Young Adult |
顯示於: | 醫學系 |
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