Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K/AKT pathway
Journal
European journal of nutrition
Journal Volume
53
Journal Issue
3
Date Issued
2014-04
Author(s)
Abstract
Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to overexpress the adiponectin receptor 1 (AdipoR1) in HepG2 cells to define the role of adiponectin and its receptor 1 in the development of fatty liver syndrome.
Subjects
Adiponectin receptor 1 | Apoptosis | HepG2 | Lipid metabolism | PI3K/AKT
SDGs
Other Subjects
acyl coenzyme A oxidase; adenosine triphosphate; adiponectin; adiponectin receptor 1; carnitine palmitoyltransferase I; cytochrome c oxidase; fatty acid transporter; fatty acid transporter 2; lentivirus vector; palmitic acid; peroxisome proliferator activated receptor alpha; peroxisome proliferator activated receptor coactivator 1 alpha; phosphatidylinositol 3 kinase; protein kinase B; realtime polymerase chain reaction; transactivator protein; unclassified drug; adenosine triphosphate; adiponectin; adiponectin receptor; ADIPOQ protein, human; AKT1 protein, human; enzyme inhibitor; fatty acid; palmitic acid; phosphatidylinositol 3 kinase; protein kinase B; recombinant protein; apoptosis; article; cell strain HepG2; cell survival; cell viability; controlled study; enzyme inhibition; enzyme phosphorylation; fatty acid metabolism; fatty liver; gene expression regulation; gene overexpression; human; human cell; liver cell; nonhuman; protein expression; signal transduction; transcription regulation; upregulation; agonists; animal; antagonists and inhibitors; cell survival; chemistry; cytology; drug effects; energy metabolism; enzymology; gene expression regulation; genetics; HepG2 cell line; metabolism; phosphorylation; protein processing; signal transduction; swine; Adenosine Triphosphate; Adiponectin; Animals; Apoptosis; Cell Survival; Energy Metabolism; Enzyme Inhibitors; Fatty Acids, Nonesterified; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Palmitic Acid; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Adiponectin; Recombinant Proteins; Signal Transduction; Sus scrofa
Type
journal article