https://scholars.lib.ntu.edu.tw/handle/123456789/584439
標題: | NRG1 genetic variant influences the efficacy of androgen-deprivation therapy in men with prostate cancer | 作者: | Huang S.-P. Chen Y.-T. Chen L.-C. Lee C.-H. CHAO-YUAN HUANG Yu C.-C. Lin V.C. Lu T.-L. Bao B.-Y. |
關鍵字: | Androgen-deprivation therapy; Meta-analysis; Neuregulin; Prostate cancer; Survival | 公開日期: | 2021 | 出版社: | MDPI AG | 卷: | 9 | 期: | 5 | 起(迄)頁: | 528 | 來源出版物: | Biomedicines | 摘要: | Neuregulins (NRGs) activate receptor tyrosine kinases of the ErbB family, and play essential roles in the proliferation, survival, and differentiation of normal and malignant tissue cells. We hypothesized that genetic variants of NRG signalling pathway genes may influence treatment outcomes in prostate cancer. To test this hypothesis, we performed a comprehensive analysis to evaluate the associations of 459 single-nucleotide polymorphisms in 19 NRG pathway genes with cancer-specific survival (CSS), overall survival (OS), and progression-free survival (PFS) in 630 patients with prostate cancer receiving androgen-deprivation therapy (ADT). After multivariate Cox regression and multiple testing correction, we found that NRG1 rs144160282 C > T is significantly associated with worsening CSS, OS, and PFS during ADT. Further analysis showed that low expression of NRG1 is closely related to prostate cancer, as indicated by a high Gleason score, an advanced stage, and a shorter PFS rate. Meta-analysis of 16 gene expression datasets of 1,081 prostate cancer samples and 294 adjacent normal samples indicate lower NRG1 expression in the former compared with the latter (p < 0.001). These results suggest that NRG1 rs144160282 might be a prognostic predictor of the efficacy of ADT. Further studies are required to confirm the significance of NRG1 as a biomarker and therapeutic target for prostate cancer. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106654576&doi=10.3390%2fbiomedicines9050528&partnerID=40&md5=e0d699d20675e57438be79eeb31f4bc4 https://scholars.lib.ntu.edu.tw/handle/123456789/584439 |
ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines9050528 |
顯示於: | 醫學系 |
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