https://scholars.lib.ntu.edu.tw/handle/123456789/584447
Title: | Genetic analysis identifies the role of HLF in renal cell carcinoma | Authors: | CHAO-YUAN HUANG HUANG S.-P. HSUEH Y.-M. CHEN L.-C. LU T.-L. BAO B.-Y. |
Keywords: | Circadian rhythm; Metastasis-free survival; Overall survival; Renal cell carcinoma; Single nucleotide polymorphism | Issue Date: | 2020 | Publisher: | International Institute of Anticancer Research | Journal Volume: | 17 | Journal Issue: | 6 | Start page/Pages: | 827-833 | Source: | Cancer Genomics and Proteomics | Abstract: | Background/Aim: Circadian rhythm is an internal clock that regulates the cycles of many biological functions. Epidemiological studies have linked aberrant circadian rhythm to an increased susceptibility to cancer and poor patient prognosis. However, there remains a gap in our understanding of genetic variants related to the circadian pathway in renal cell carcinoma (RCC) progression. Patients and Methods: We examined the associations of 150 single nucleotide polymorphisms (SNPs) in 12 core circadian pathway genes with RCC risk and survival in 630 patients with RCC and controls. Results: After adjusting for multiple comparisons and performing multivariate analyses, we found that the HLF rs6504958 polymorphism was significantly associated with RCC risk (q<0.05), whereas, no SNP association was significant for survival. Furthermore, the rs6504958 G allele was associated with reduced expression of HLF; consequently, a lower HLF expression was correlated with more advanced RCC. Moreover, a metaanalysis of six kidney cancer gene expression datasets demonstrated that an elevated HLF expression was associated with a favorable prognosis in patients with RCC (hazard ratio=0.70, 95% confidence interval=0.65-0.76, p<0.001). Conclusion: These findings implicate the potential protective role of HLF in the progression of RCC. ? 2020 International Institute of Anticancer Research. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094652297&doi=10.21873%2fCGP.20236&partnerID=40&md5=01a63f944dda4fd73e59e5fbe8d8db0a https://scholars.lib.ntu.edu.tw/handle/123456789/584447 |
ISSN: | 1109-6535 | DOI: | 10.21873/CGP.20236 | SDG/Keyword: | adult; advanced cancer; aged; allele; Article; bioinformatics; cancer prognosis; cancer survival; carcinogenesis; circadian rhythm; confidence interval; controlled study; data analysis software; female; gene; gene expression; genetic analysis; genetic association; genetic susceptibility; genetic variability; hazard ratio; HLF gene; human; major clinical study; male; metastasis free survival; multivariate analysis; overall survival; renal cell carcinoma; single nucleotide polymorphism |
Appears in Collections: | 醫學系 |
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