https://scholars.lib.ntu.edu.tw/handle/123456789/584453
標題: | Genetic analysis reveals a significant contribution of ces1 to prostate cancer progression in taiwanese men | 作者: | Ke C.-C. Chen L.-C. Yu C.-C. Cheng W.-C. CHAO-YUAN HUANG Lin V.C. Lu T.-L. Huang S.-P. Bao B.-Y. |
關鍵字: | Biomarker; Carboxylesterase; Prognosis; Progression; Prostate cancer | 公開日期: | 2020 | 出版社: | MDPI AG | 卷: | 12 | 期: | 5 | 起(迄)頁: | 1346 | 來源出版物: | Cancers | 摘要: | The genes that influence prostate cancer progression remain largely unknown. Since the carboxylesterase gene family plays a crucial role in xenobiotic metabolism and lipid/cholesterol homeostasis, we hypothesize that genetic variants in carboxylesterase genes may influence clinical outcomes for prostate cancer patients. A total of 478 (36 genotyped and 442 imputed) single nucleotide polymorphisms (SNPs) in five genes of the carboxylesterase family were assessed in terms of their associations with biochemical recurrence (BCR)-free survival in 643 Taiwanese patients with prostate cancer who underwent radical prostatectomy. The strongest association signal was shown in CES1 (P = 9.64×10-4 for genotyped SNP rs8192935 and P = 8.96 × 10-5 for imputed SNP rs8192950). After multiple test correction and adjustment for clinical covariates, CES1 rs8192935 (P = 9.67 × 10-4) and rs8192950 (P = 9.34 × 10-5) remained significant. These SNPs were correlated with CES1 expression levels, which in turn were associated with prostate cancer aggressiveness. Furthermore, our meta-analysis, including eight studies, indicated that a high CES1 expression predicted better outcomes among prostate cancer patients (hazard ratio 0.82, 95% confidence interval 0.70–0.97, P = 0.02). In conclusion, our findings suggest that CES1 rs8192935 and rs8192950 are associated with BCR and that CES1 plays a tumor suppressive role in prostate cancer. ? 2020 by the authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085618730&doi=10.3390%2fcancers12051346&partnerID=40&md5=e8fba74c2d9551cbe33965dab7136665 https://scholars.lib.ntu.edu.tw/handle/123456789/584453 |
ISSN: | 2072-6694 | DOI: | 10.3390/cancers12051346 | SDG/關鍵字: | carboxylesterase; carboxylesterase 1; unclassified drug; aged; Article; biochemical recurrence free survival; bioinformatics; cancer growth; cancer recurrence; cancer staging; cancer survival; CES1 gene; clinical feature; clinical outcome; controlled study; gene; gene expression; gene function; genetic analysis; genetic association; genetic variability; genotype; human; human tissue; major clinical study; male; prostate cancer; prostatectomy; single nucleotide polymorphism; Taiwanese |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。