|Title:||Cancer stem cell gene variants predict disease recurrence in patients treated with radical prostatectomy for prostate cancer||Authors:||Lin V.C.
|Keywords:||Cancer stem cell; POU5F1; Prostate cancer; Radical prostatectomy; Recurrence; Single nucleotide polymorphism||Issue Date:||2017||Publisher:||Ivyspring International Publisher||Journal Volume:||14||Journal Issue:||12||Start page/Pages:||1301-1306||Source:||International Journal of Medical Sciences||Abstract:||
Background: Cancer stem cells (CSCs) are involved in tumor progression and drug resistance. We hypothesized that variants in CSC marker genes influence treatment outcomes in prostate cancer. Methods: Ten potentially functional single nucleotide polymorphisms (SNPs) in seven prostate CSC marker genes, TACSTD2, PROM1, ITGA2, POU5F1, EZH2, PSCA, and CD44, were selected for analysis of their association with disease recurrence by Kaplan-Meier analysis and Cox regression in a cohort of 320 patients with localized prostate cancer receiving radical prostatectomy. Results: We identified one independent SNP, rs2394882, in POU5F1 that was associated with prostate cancer recurrence (hazard ratio 0.32, 95% confidence interval 0.14-0.71, P = 0.005) after adjustment for known clinical predictors. Further in silico functional analyses revealed that rs2394882 affects POU5F1 expression, which in turn is significantly correlated with prostate cancer aggressiveness and patient prognosis. Conclusion: Our results suggest that rs2394882 is prognostically relevant in prostate cancer, possibly by modulating the expression of the CSC gene POU5F1. ? Ivyspring International Publisher.
|ISSN:||1449-1907||DOI:||10.7150/ijms.21428||SDG/Keyword:||Hermes antigen; octamer transcription factor 4; prostate stem cell antigen; transcription factor EZH2; cell adhesion molecule; octamer transcription factor 4; POU5F1 protein, human; tumor marker; Article; cancer patient; cancer prognosis; cancer recurrence; cancer stem cell; CD44 gene; cohort analysis; controlled study; EZH2 gene; gene; gene expression; genetic variability; human; ITGA2 gene; major clinical study; male; POU5F1 gene; PROM1 gene; prostate cancer; prostatectomy; PSCA gene; single nucleotide polymorphism; TACSTD2 gene; treatment outcome; aged; cancer stem cell; genetics; genotype; metabolism; middle aged; pathology; prognosis; proportional hazards model; prostate; prostate tumor; prostatectomy; single nucleotide polymorphism; Taiwan; tumor recurrence; Aged; Biomarkers, Tumor; Cell Adhesion Molecules; Cohort Studies; Genotype; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Octamer Transcription Factor-3; Polymorphism, Single Nucleotide; Prognosis; Proportional Hazards Models; Prostate; Prostatectomy; Prostatic Neoplasms; Taiwan
|Appears in Collections:||醫學系|
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