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  5. High-Risk Human Papillomaviruses May Have an Important Role in Non-Oral Habits-Associated Oral Squamous Cell Carcinomas in Taiwan
 
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High-Risk Human Papillomaviruses May Have an Important Role in Non-Oral Habits-Associated Oral Squamous Cell Carcinomas in Taiwan

Journal
American Journal of Clinical Pathology
Journal Volume
120
Journal Issue
6
Pages
909-916
Date Issued
2003
Author(s)
JULIA YU-FONG CHANG  
Lin M.-C.
CHUN-PIN CHIANG  
DOI
10.1309/C5P6NUQ2NW6LCTBP
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345258410&doi=10.1309%2fC5P6NUQ2NW6LCTBP&partnerID=40&md5=013d3c57f1e3301e0b76ef8902e8e7f2
https://scholars.lib.ntu.edu.tw/handle/123456789/584897
Abstract
To evaluate the etiologic role of human papillomavirus (HPV) in oral carcinogenesis, DNA samples were purified from 103 oral squamous cell carcinoma (OSCC) and 30 normal oral mucosal (NOM) specimens. A nested polymerase chain reaction, DNA sequencing, and gene-chip HPV typing were used to identify multiple HPV types in our samples. We found that the positive rates of all HPV types and of high-risk HPV types were significantly higher in OSCC samples (49.5% and 41.7%, respectively) than in NOM samples (6/30 [20%; P < .01] and 5/30 [17%; P < .05], respectively) and significantly higher in non-oral habits (OH)-associated OSCC samples (31/51 [61%] and 28/51 [55%], respectively) than in OH-associated OSCC samples (20/52 [38%; P < .05] and 15/52 [29%; P < .001], respectively). High-risk HPV types and all HPV types had odds ratios of 3.97 (P = .0097) and 3.92 (P = .006), respectively. Our results suggest that HPVs, particularly high-risk HPVs, might be associated with the development of OSCCs, especially the non-OH-associated OSCCs.
Subjects
High-risk HPV types; HPV; Human papillomavirus; Oral cancer
SDGs

[SDGs]SDG3

Other Subjects
DNA; adult; aged; article; carcinogenesis; controlled study; DNA sequence; female; human; human tissue; major clinical study; male; mouth carcinoma; mouth mucosa; nonhuman; Papilloma virus; polymerase chain reaction; priority journal; virus identification; virus typing
Publisher
American Society of Clinical Pathologists
Type
journal article

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