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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設癌醫中心醫院(臺大癌醫)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/584946
Title: From germ theory to germ therapy
Authors: CHIEH-CHANG CHEN 
YEN-NIEN CHEN 
JYH-MING LIOU 
MING-SHIANG WU 
Taiwan Gastrointestinal Disease
Helicobacter Consortium
Issue Date: 2019
Publisher: John Wiley and Sons Inc.
Journal Volume: 35
Journal Issue: 2
Start page/Pages: 73-82
Source: Kaohsiung Journal of Medical Sciences
Abstract: 
Germ theory of disease and Koch’s postulates has been governing our understanding of the role of microbes in human health since 19th century. The discovery of Helicobacter pylori (H. pylori) and H. pylori associated diseases has typically represented the concept and framework of Koch’s postulates. Eradication of H. pylori to prevent peptic ulcers recurrence and gastric cancer is the triumph of this microbiology paradigm. Advances of next generation sequencing provide great insight into the unculturable microbes and show trillions of microbes have evolved with human beings. Research into the microbiome-the microbial communities (microbiota) and the host environment that they inhabit-has changed our understanding about microbes in human health and disease. The gut microbiota, the largest reservoir of the microbiome in human, plays a critical role in our catabolic-metabolism and immunity. This review will show the changes of the view of microbes on human health. We will briefly discuss dysbiosis, the disruption of symbiotic relationship between the host and microbiota, and the associated diseases. This leads to an idea to manipulate the microbiota, either by restoring missing functions or by eliminating harmful functions, to prevent or treat a variety of diseases. Current evidences of two common germ therapies, fecal microbiota transplantation and probiotics, in treating diseases will be reviewed. ? 2019 The Authors.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062636449&doi=10.1002%2fkjm2.12011&partnerID=40&md5=6426435f57f50ac4f4cfc27b72e324bd
https://scholars.lib.ntu.edu.tw/handle/123456789/584946
ISSN: 1607-551X
DOI: 10.1002/kjm2.12011
SDG/Keyword: probiotic agent; probiotic agent; dysbiosis; fecal microbiota transplantation; feces microflora; germ theory of disease; germ therapy; host; human; microflora; microorganism; nonhuman; Review; symbiosis; therapy; clinical trial (topic); diseases; drug effect; fecal microbiota transplantation; intestine flora; Clinical Trials as Topic; Disease; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Germ Theory of Disease; Humans; Probiotics
[SDGs]SDG3
Appears in Collections:醫學院附設癌醫中心醫院(臺大癌醫)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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