Effective indicators for diagnosis of oral cancer using optical coherence tomography
Journal
Optics Express
Journal Volume
16
Journal Issue
20
Pages
15847-15862
Date Issued
2008
Author(s)
Tsai M.-T.
Lee C.-K.
Yu C.-H.
Chang C.-C.
Wang Y.-M.
Yang C.C.
Abstract
A swept-source optical coherence tomography system is used to clinically scan oral precancer and cancer patients for statistically analyzing the effective indicators of diagnosis. Three indicators are considered, including the standard deviation (SD) of an A-mode scan signal profile, the exponential decay constant (α) of an A-mode-scan spatial-frequency spectrum, and the epithelium thickness (T) when the boundary between epithelium and lamina propria can still be identified. Generally, in abnormal mucosa, the standard deviation becomes larger, the decay constant of the spatial-frequency spectrum becomes smaller, and epithelium becomes thicker. The sensitivity and specificity of the three indicators are discussed based on universal and individual relative criteria. It is found that SD and a are good diagnosis indicators for moderate dysplasia and squamous cell carcinoma. On the other hand, T is a good diagnosis indicator for epithelia hyperplasia and moderate dysplasia. ? 2008 Optical Society of America.
SDGs
Other Subjects
Diseases; Optical tomography; Spectroscopy; Statistics; Tomography; Cancer patients; Diagnosis indicators; Exponential decays; Sensitivity and specificity; Spatial frequency spectrums; Squamous cell carcinoma; Standard deviation; Swept source optical coherence tomographies; Diagnosis; adult; aged; article; diagnostic imaging; epithelium; equipment design; female; human; hyperplasia; instrumentation; male; methodology; middle aged; mouth mucosa; mouth tumor; optical coherence tomography; pathology; signal processing; squamous cell carcinoma; Adult; Aged; Carcinoma, Squamous Cell; Diagnostic Imaging; Epithelium; Equipment Design; Female; Humans; Hyperplasia; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Signal Processing, Computer-Assisted; Tomography, Optical Coherence
Publisher
Optical Society of America (OSA)
Type
journal article