https://scholars.lib.ntu.edu.tw/handle/123456789/585075
標題: | Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy | 作者: | HSIN-MING CHEN Yu C.-H. Tu P.-C. Yeh C.-Y. Tsai T. CHUN-PIN CHIANG |
公開日期: | 2005 | 卷: | 37 | 期: | 2 | 起(迄)頁: | 114-122 | 來源出版物: | Lasers in Surgery and Medicine | 摘要: | Background and Objectives: Our recent studies showed that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol using a light-emitting diode (LED) light source is an effective and successful treatment modality for five cases of oral verrucous hyperplasia (OVH) and one case of verrucous carcinoma. In this study, we treated eight OVH lesions with the same topical ALA-PDT protocol to further confirm the efficacy of this protocol on OVH lesions. In addition, our recent study demonstrated an unsatisfactory clinical outcome for 24 oral leukoplakia (OL) lesions treated once a week by the same topical ALA-PDT protocol. Therefore, in this study 24 OL lesions were treated twice a week by the same protocol to compare whether the twice-a-week treatment modality could result in a better clinical outcome than the once-a-week treatment modality. Study Design/Materials and Methods: In this study, 8 OVH and 24 OL lesions were treated by the same topical ALA-PDT once a week and twice a week, respectively. Results: All the former eight OVH lesions treated once a week showed complete response (CR) after 2-5 (mean, 3.8) treatments of ALA-PDT. The latter 24 OL lesions treated twice a week demonstrated CR in 8, partial response (PR) in 16, and no response in none. The present 24 OL lesions treated twice a week had a significantly better clinical outcome than the previous 24 OL lesions treated once a week (P = 0.000, chi-square test). Conclusions: We conclude that complete regression of OVH lesions can be achieved by less than six treatments of topical ALA-PDT once a week. Although the response of OL lesions to the topical ALA-PDT is not as good as the response of OVH lesions to the same therapy, all OL lesions can have at least PR after eight treatments with the topical ALA-PDT twice a week. In addition, OL lesions treated twice a week have a significantly better clinical outcome than OL lesions treated once a week. ? 2005 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-24644507158&doi=10.1002%2flsm.20214&partnerID=40&md5=ca51d8ded5af92aeb05778fad6d20503 https://scholars.lib.ntu.edu.tw/handle/123456789/585075 |
ISSN: | 0196-8092 | DOI: | 10.1002/lsm.20214 | SDG/關鍵字: | aminolevulinic acid; adult; aged; article; clinical article; clinical trial; drug dose regimen; drug efficacy; drug response; female; human; leukoplakia; male; mouth disease; oral verrucous hyperplasia; photodynamic therapy; priority journal; radiation dose; radiation response; Administration, Topical; Adult; Aged; Aminolevulinic Acid; Carcinoma, Verrucous; Drug Administration Schedule; Female; Humans; Hyperplasia; Leukoplakia, Oral; Male; Middle Aged; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Treatment Outcome |
顯示於: | 牙醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。